Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.

Parkinson's disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. However, these oscillations are phasic, and there is a growing body of evidence suggesting that beta burst duration may be of critical importance to motor symptoms. This makes...

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Autores principales: Benoit Duchet, Filippo Ghezzi, Gihan Weerasinghe, Gerd Tinkhauser, Andrea A Kühn, Peter Brown, Christian Bick, Rafal Bogacz
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Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/9a22e0788eb0480c85f4244b535d38df
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spelling oai:doaj.org-article:9a22e0788eb0480c85f4244b535d38df2021-12-02T19:57:34ZAverage beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.1553-734X1553-735810.1371/journal.pcbi.1009116https://doaj.org/article/9a22e0788eb0480c85f4244b535d38df2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009116https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Parkinson's disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. However, these oscillations are phasic, and there is a growing body of evidence suggesting that beta burst duration may be of critical importance to motor symptoms. This makes insights into the dynamics of beta bursting generation valuable, in particular to refine closed-loop deep brain stimulation in Parkinson's disease. In this study, we ask the question "Can average burst duration reveal how dynamics change between the ON and OFF medication states?". Our analysis of local field potentials from the subthalamic nucleus demonstrates using linear surrogates that the system generating beta oscillations is more likely to act in a non-linear regime OFF medication and that the change in a non-linearity measure is correlated with motor impairment. In addition, we pinpoint the simplest dynamical changes that could be responsible for changes in the temporal patterning of beta oscillations between medication states by fitting to data biologically inspired models, and simpler beta envelope models. Finally, we show that the non-linearity can be directly extracted from average burst duration profiles under the assumption of constant noise in envelope models. This reveals that average burst duration profiles provide a window into burst dynamics, which may underlie the success of burst duration as a biomarker. In summary, we demonstrate a relationship between average burst duration profiles, dynamics of the system generating beta oscillations, and motor impairment, which puts us in a better position to understand the pathology and improve therapies such as deep brain stimulation.Benoit DuchetFilippo GhezziGihan WeerasingheGerd TinkhauserAndrea A KühnPeter BrownChristian BickRafal BogaczPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009116 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Benoit Duchet
Filippo Ghezzi
Gihan Weerasinghe
Gerd Tinkhauser
Andrea A Kühn
Peter Brown
Christian Bick
Rafal Bogacz
Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.
description Parkinson's disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. However, these oscillations are phasic, and there is a growing body of evidence suggesting that beta burst duration may be of critical importance to motor symptoms. This makes insights into the dynamics of beta bursting generation valuable, in particular to refine closed-loop deep brain stimulation in Parkinson's disease. In this study, we ask the question "Can average burst duration reveal how dynamics change between the ON and OFF medication states?". Our analysis of local field potentials from the subthalamic nucleus demonstrates using linear surrogates that the system generating beta oscillations is more likely to act in a non-linear regime OFF medication and that the change in a non-linearity measure is correlated with motor impairment. In addition, we pinpoint the simplest dynamical changes that could be responsible for changes in the temporal patterning of beta oscillations between medication states by fitting to data biologically inspired models, and simpler beta envelope models. Finally, we show that the non-linearity can be directly extracted from average burst duration profiles under the assumption of constant noise in envelope models. This reveals that average burst duration profiles provide a window into burst dynamics, which may underlie the success of burst duration as a biomarker. In summary, we demonstrate a relationship between average burst duration profiles, dynamics of the system generating beta oscillations, and motor impairment, which puts us in a better position to understand the pathology and improve therapies such as deep brain stimulation.
format article
author Benoit Duchet
Filippo Ghezzi
Gihan Weerasinghe
Gerd Tinkhauser
Andrea A Kühn
Peter Brown
Christian Bick
Rafal Bogacz
author_facet Benoit Duchet
Filippo Ghezzi
Gihan Weerasinghe
Gerd Tinkhauser
Andrea A Kühn
Peter Brown
Christian Bick
Rafal Bogacz
author_sort Benoit Duchet
title Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.
title_short Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.
title_full Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.
title_fullStr Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.
title_full_unstemmed Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.
title_sort average beta burst duration profiles provide a signature of dynamical changes between the on and off medication states in parkinson's disease.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/9a22e0788eb0480c85f4244b535d38df
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