CB2 Receptor Involvement in the Treatment of Substance Use Disorders

The pharmacological modulation of the cannabinoid receptor 2 (CB2r) has emerged as a promising potential therapeutic option in addiction. The purpose of this review was to determine the functional involvement of CB2r in the effects produced by drugs of abuse at the central nervous system (CNS) level...

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Autores principales:	Francisco Navarrete, María S. García-Gutiérrez, Ani Gasparyan, Daniela Navarro, Jorge Manzanares
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cannabinoid 2 receptor substance use disorder reward system alcohol cocaine nicotine Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9a2301fb7cdd4bb6b91e343bb7702204
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spelling	oai:doaj.org-article:9a2301fb7cdd4bb6b91e343bb77022042021-11-25T16:51:48ZCB2 Receptor Involvement in the Treatment of Substance Use Disorders10.3390/biom111115562218-273Xhttps://doaj.org/article/9a2301fb7cdd4bb6b91e343bb77022042021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1556https://doaj.org/toc/2218-273XThe pharmacological modulation of the cannabinoid receptor 2 (CB2r) has emerged as a promising potential therapeutic option in addiction. The purpose of this review was to determine the functional involvement of CB2r in the effects produced by drugs of abuse at the central nervous system (CNS) level by assessing evidence from preclinical and clinical studies. In rodents, several reports suggest the functional involvement of CB2r in the effects produced by drugs of abuse such as alcohol, cocaine, or nicotine. In addition, the discovery of CB2r in brain areas that are part of the reward system supports the relevance of CB2r in the field of addiction. Interestingly, animal studies support that the CB2r regulates anxiety and depression behavioral traits. Due to its frequent comorbidity with neuropsychiatric disorders, these pharmacological actions may be of great interest in managing SUD. Preliminary clinical trials are focused on exploring the therapeutic potential of modulating CB2r in treating addictive disorders. These promising results support the development of new pharmacological tools regulating the CB2r that may help to increase the therapeutic success in the management of SUD.Francisco NavarreteMaría S. García-GutiérrezAni GasparyanDaniela NavarroJorge ManzanaresMDPI AGarticlecannabinoid 2 receptorsubstance use disorderreward systemalcoholcocainenicotineMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1556, p 1556 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cannabinoid 2 receptor substance use disorder reward system alcohol cocaine nicotine Microbiology QR1-502
spellingShingle	cannabinoid 2 receptor substance use disorder reward system alcohol cocaine nicotine Microbiology QR1-502 Francisco Navarrete María S. García-Gutiérrez Ani Gasparyan Daniela Navarro Jorge Manzanares CB2 Receptor Involvement in the Treatment of Substance Use Disorders
description	The pharmacological modulation of the cannabinoid receptor 2 (CB2r) has emerged as a promising potential therapeutic option in addiction. The purpose of this review was to determine the functional involvement of CB2r in the effects produced by drugs of abuse at the central nervous system (CNS) level by assessing evidence from preclinical and clinical studies. In rodents, several reports suggest the functional involvement of CB2r in the effects produced by drugs of abuse such as alcohol, cocaine, or nicotine. In addition, the discovery of CB2r in brain areas that are part of the reward system supports the relevance of CB2r in the field of addiction. Interestingly, animal studies support that the CB2r regulates anxiety and depression behavioral traits. Due to its frequent comorbidity with neuropsychiatric disorders, these pharmacological actions may be of great interest in managing SUD. Preliminary clinical trials are focused on exploring the therapeutic potential of modulating CB2r in treating addictive disorders. These promising results support the development of new pharmacological tools regulating the CB2r that may help to increase the therapeutic success in the management of SUD.
format	article
author	Francisco Navarrete María S. García-Gutiérrez Ani Gasparyan Daniela Navarro Jorge Manzanares
author_facet	Francisco Navarrete María S. García-Gutiérrez Ani Gasparyan Daniela Navarro Jorge Manzanares
author_sort	Francisco Navarrete
title	CB2 Receptor Involvement in the Treatment of Substance Use Disorders
title_short	CB2 Receptor Involvement in the Treatment of Substance Use Disorders
title_full	CB2 Receptor Involvement in the Treatment of Substance Use Disorders
title_fullStr	CB2 Receptor Involvement in the Treatment of Substance Use Disorders
title_full_unstemmed	CB2 Receptor Involvement in the Treatment of Substance Use Disorders
title_sort	cb2 receptor involvement in the treatment of substance use disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9a2301fb7cdd4bb6b91e343bb7702204
work_keys_str_mv	AT francisconavarrete cb2receptorinvolvementinthetreatmentofsubstanceusedisorders AT mariasgarciagutierrez cb2receptorinvolvementinthetreatmentofsubstanceusedisorders AT anigasparyan cb2receptorinvolvementinthetreatmentofsubstanceusedisorders AT danielanavarro cb2receptorinvolvementinthetreatmentofsubstanceusedisorders AT jorgemanzanares cb2receptorinvolvementinthetreatmentofsubstanceusedisorders
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CB2 Receptor Involvement in the Treatment of Substance Use Disorders

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