Novel targets for immunotherapy in glomerulonephritis

Mary H FosterDepartment of Medicine and Research Service, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USAAbstract: Glomerulonephritis is a common cause of chronic kidney disease and end stage renal failure. Current therapy relies on variably eff...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Mary H Foster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9a26cf120cb94ec1ad75138f3cbf9a4e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a26cf120cb94ec1ad75138f3cbf9a4e
record_format	dspace
spelling	oai:doaj.org-article:9a26cf120cb94ec1ad75138f3cbf9a4e2021-12-02T07:45:51ZNovel targets for immunotherapy in glomerulonephritis1177-54751177-5491https://doaj.org/article/9a26cf120cb94ec1ad75138f3cbf9a4e2008-09-01T00:00:00Zhttp://www.dovepress.com/novel-targets-for-immunotherapy-in-glomerulonephritis-a2302https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Mary H FosterDepartment of Medicine and Research Service, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USAAbstract: Glomerulonephritis is a common cause of chronic kidney disease and end stage renal failure. Current therapy relies on variably effective, nonspecific and toxic immunosuppression. Recent insights into underlying biology and disease pathogenesis in human glomerulonephritis combined with advances in the fields of inflammation and autoimmunity promise a cadre of novel targeted interventions. This review highlights the therapeutic potential of two antigens, alpha3 (IV)NC1 collagen and podocyte neutral endopeptidase, and two cell signaling and effector molecules, IgG Fc receptors and complement, judged to be particularly amenable to therapeutic manipulation in man. It is anticipated that continued dissection of pathogenesis in the diverse disorders that comprise the glomerulonephritides will provide the basis for individualized disease-specific therapy.Keywords: glomerulonephritis, immunotherapy, Goodpasture syndrome, membranous nephropathy Mary H FosterDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 531-545 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mary H Foster Novel targets for immunotherapy in glomerulonephritis
description	Mary H FosterDepartment of Medicine and Research Service, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USAAbstract: Glomerulonephritis is a common cause of chronic kidney disease and end stage renal failure. Current therapy relies on variably effective, nonspecific and toxic immunosuppression. Recent insights into underlying biology and disease pathogenesis in human glomerulonephritis combined with advances in the fields of inflammation and autoimmunity promise a cadre of novel targeted interventions. This review highlights the therapeutic potential of two antigens, alpha3 (IV)NC1 collagen and podocyte neutral endopeptidase, and two cell signaling and effector molecules, IgG Fc receptors and complement, judged to be particularly amenable to therapeutic manipulation in man. It is anticipated that continued dissection of pathogenesis in the diverse disorders that comprise the glomerulonephritides will provide the basis for individualized disease-specific therapy.Keywords: glomerulonephritis, immunotherapy, Goodpasture syndrome, membranous nephropathy
format	article
author	Mary H Foster
author_facet	Mary H Foster
author_sort	Mary H Foster
title	Novel targets for immunotherapy in glomerulonephritis
title_short	Novel targets for immunotherapy in glomerulonephritis
title_full	Novel targets for immunotherapy in glomerulonephritis
title_fullStr	Novel targets for immunotherapy in glomerulonephritis
title_full_unstemmed	Novel targets for immunotherapy in glomerulonephritis
title_sort	novel targets for immunotherapy in glomerulonephritis
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/9a26cf120cb94ec1ad75138f3cbf9a4e
work_keys_str_mv	AT maryhfoster noveltargetsforimmunotherapyinglomerulonephritis
_version_	1718399175601684480

Novel targets for immunotherapy in glomerulonephritis

Ejemplares similares