Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism.
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Nature Portfolio
2018
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oai:doaj.org-article:9a2754d11dc34b7e92b8fd4db1a27cbf2021-12-02T14:39:45ZRifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism10.1038/s41467-018-06587-22041-1723https://doaj.org/article/9a2754d11dc34b7e92b8fd4db1a27cbf2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06587-2https://doaj.org/toc/2041-1723Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism.James PeekMirjana LilicDaniel MontielAleksandr MilshteynIan WoodworthJohn B. BigginsMelinda A. TerneiPaula Y. CalleMichael DanzigerThulasi WarrierKohta SaitoNathaniel BraffmanAllison FayMichael S. GlickmanSeth A. DarstElizabeth A. CampbellSean F. BradyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q James Peek Mirjana Lilic Daniel Montiel Aleksandr Milshteyn Ian Woodworth John B. Biggins Melinda A. Ternei Paula Y. Calle Michael Danziger Thulasi Warrier Kohta Saito Nathaniel Braffman Allison Fay Michael S. Glickman Seth A. Darst Elizabeth A. Campbell Sean F. Brady Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| description |
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism. |
| format |
article |
| author |
James Peek Mirjana Lilic Daniel Montiel Aleksandr Milshteyn Ian Woodworth John B. Biggins Melinda A. Ternei Paula Y. Calle Michael Danziger Thulasi Warrier Kohta Saito Nathaniel Braffman Allison Fay Michael S. Glickman Seth A. Darst Elizabeth A. Campbell Sean F. Brady |
| author_facet |
James Peek Mirjana Lilic Daniel Montiel Aleksandr Milshteyn Ian Woodworth John B. Biggins Melinda A. Ternei Paula Y. Calle Michael Danziger Thulasi Warrier Kohta Saito Nathaniel Braffman Allison Fay Michael S. Glickman Seth A. Darst Elizabeth A. Campbell Sean F. Brady |
| author_sort |
James Peek |
| title |
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| title_short |
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| title_full |
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| title_fullStr |
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| title_full_unstemmed |
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| title_sort |
rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/9a2754d11dc34b7e92b8fd4db1a27cbf |
| work_keys_str_mv |
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| _version_ |
1718390548672282624 |