The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Abstract Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP pati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tongtian Ni, Ying Chen, Bing Zhao, Li Ma, Yi Yao, Erzhen Chen, Weijun Zhou, Enqiang Mao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a28c05cf6914b3e931b06fc709e2179
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a28c05cf6914b3e931b06fc709e2179
record_format	dspace
spelling	oai:doaj.org-article:9a28c05cf6914b3e931b06fc709e21792021-12-02T17:41:28ZThe impact of fluid resuscitation via colon on patients with severe acute pancreatitis10.1038/s41598-021-92065-72045-2322https://doaj.org/article/9a28c05cf6914b3e931b06fc709e21792021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92065-7https://doaj.org/toc/2045-2322Abstract Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups were analyzed. Of the 181 patients included in the analysis, the FRVC group received more fluid volume and reached the endpoint of blood volume expansion ahead of the non-FRVC group. After the early fluid resuscitation, the inflammation indicators in the FRVC group were lower. The rate of mechanical ventilation and the incidence of hypernatremia also decreased significantly. Using pure water for FRVC was more helpful to reduce hypernatremia. However, Kaplan–Meier 90-day survival between the two groups showed no difference. These results suggest that the combination of FRVC might benefit SAP patients in the early stage of fluid resuscitation, but there is no difference between the prognosis of SAP patients and that of conventional fluid resuscitation. Further prospective study is needed to evaluate the effect of FRVC on SAP patients.Tongtian NiYing ChenBing ZhaoLi MaYi YaoErzhen ChenWeijun ZhouEnqiang MaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongtian Ni Ying Chen Bing Zhao Li Ma Yi Yao Erzhen Chen Weijun Zhou Enqiang Mao The impact of fluid resuscitation via colon on patients with severe acute pancreatitis
description	Abstract Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups were analyzed. Of the 181 patients included in the analysis, the FRVC group received more fluid volume and reached the endpoint of blood volume expansion ahead of the non-FRVC group. After the early fluid resuscitation, the inflammation indicators in the FRVC group were lower. The rate of mechanical ventilation and the incidence of hypernatremia also decreased significantly. Using pure water for FRVC was more helpful to reduce hypernatremia. However, Kaplan–Meier 90-day survival between the two groups showed no difference. These results suggest that the combination of FRVC might benefit SAP patients in the early stage of fluid resuscitation, but there is no difference between the prognosis of SAP patients and that of conventional fluid resuscitation. Further prospective study is needed to evaluate the effect of FRVC on SAP patients.
format	article
author	Tongtian Ni Ying Chen Bing Zhao Li Ma Yi Yao Erzhen Chen Weijun Zhou Enqiang Mao
author_facet	Tongtian Ni Ying Chen Bing Zhao Li Ma Yi Yao Erzhen Chen Weijun Zhou Enqiang Mao
author_sort	Tongtian Ni
title	The impact of fluid resuscitation via colon on patients with severe acute pancreatitis
title_short	The impact of fluid resuscitation via colon on patients with severe acute pancreatitis
title_full	The impact of fluid resuscitation via colon on patients with severe acute pancreatitis
title_fullStr	The impact of fluid resuscitation via colon on patients with severe acute pancreatitis
title_full_unstemmed	The impact of fluid resuscitation via colon on patients with severe acute pancreatitis
title_sort	impact of fluid resuscitation via colon on patients with severe acute pancreatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9a28c05cf6914b3e931b06fc709e2179
work_keys_str_mv	AT tongtianni theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT yingchen theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT bingzhao theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT lima theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT yiyao theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT erzhenchen theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT weijunzhou theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT enqiangmao theimpactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT tongtianni impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT yingchen impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT bingzhao impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT lima impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT yiyao impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT erzhenchen impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT weijunzhou impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis AT enqiangmao impactoffluidresuscitationviacolononpatientswithsevereacutepancreatitis
_version_	1718379660473008128

The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Ejemplares similares