Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas

Anastasios John Kanellopoulos,1,2 George Asimellis11LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USAPurpose: To investigate repeatability of steep and flat keratometry measurements, as well as astigmatism ax...

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Autores principales:	Kanellopoulos AJ, Asimellis G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9a28f1c6d622477c8ae0e5aad77119aa
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spelling	oai:doaj.org-article:9a28f1c6d622477c8ae0e5aad77119aa2021-12-02T05:50:35ZColor light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas1177-5483https://doaj.org/article/9a28f1c6d622477c8ae0e5aad77119aa2015-02-01T00:00:00Zhttp://www.dovepress.com/color-light-emitting-diode-reflection-topography-validation-of-keratom-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Anastasios John Kanellopoulos,1,2 George Asimellis11LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USAPurpose: To investigate repeatability of steep and flat keratometry measurements, as well as astigmatism axis in cohorts with normal range and regular astigmatic such as: eyes following laser-assisted in situ keratomileusis (LASIK) and normal population, as well as cohorts of high and irregular astigmatism such as keratoconic eyes, and keratoconic eyes following corneal collagen cross-linking, employing a novel corneal reflection topography device.Methods: Steep and flat keratometry and astigmatism axis measurement repeatability was investigated employing a novel multicolored-spot reflection topographer (Cassini) in four study groups, namely a post myopic LASIK-treated Group A, a keratoconus Group B, a post-CXL keratoconus Group C, and a control Group D of routine healthy patients. Three separate, maps were obtained employing the Cassini, enabling investigation of the intra-individual repeatability by standard deviation. Additionally we investigated in all groups,the Klyce surface irregularity indices for keratoconus, the SAI (surface asymmetry index) and the SRI (surface regularity index).Results: Flat keratometry repeatability was 0.74±0.89 (0.03 to 5.26) diopters (D) in the LASIK Group A, 0.88±1.45 (range minimum to maximum, 0.00 to 7.84) D in the keratoconic Group B, and 0.71±0.94 (0.02 to 6.23) D in the cross-linked Group C. The control Group D had flat keratometry repeatability 0.36±0.46 (0.00 to 2.71) D. Steep keratometry repeatability was 0.64±0.82 (0.01 to 4.81) D in the LASIK Group A, 0.89±1.22 (0.02 to 7.85) D in the keratoconic Group B, and 0.93±1.12 (0.04 to 5.93) D in the cross-linked Group C. The control Group D had steep keratometry repeatability 0.41±0.50 (0.00 to 3.51) D. Axis repeatability was 3.45±1.62° (0.38 to 7.78°) for the LASIK Group A, 4.12±3.17° (0.02 to 12.13°) for the keratoconic Group B, and 3.20±1.99° (0.17 to 8.61°) for the cross-linked Group C. The control Group D had axis repeatability 2.16±1.39° (0.05 to 5.86°). The SAI index measurement repeatability was 0.33±0.40 (0.01 to 2.31) in the post-LASIK Group A, 0.39±0.75 (0.00 to 7.15) in the keratoconic Group B, and 0.43±0.56 (0.05 to 3.50) in the keratoconus post-CXL Group C. The control group had SAI measurement repeatability of 0.26±0.30 (0.00 to 2.39). The SRI index repeatability was 0.22±0.17 (0.01 to 0.96) for post-LASIK Group A, 0.20±0.18 (0.00 to 1.07) in keratoconic Group B, and 0.13±0.09 (0.00 to 0.45) in the keratoconus post-CXL Group C. The control Group D had SRI measurement repeatability of 0.23±0.16 (0.00 to 0.75).Conclusion: This novel corneal topography device appears to offer very high specificity in estimating corneal keratometry and specific corneal irregularity indices, even in topographically challenging corneas such as LASIK treated, keratoconic, and cross-linked.Keywords: LED topography, point-source topography, VU topographer, axis of astigmatism, Cassini topographer, steep meridian, surface regularity index, surface asymmetry index, form factorKanellopoulos AJAsimellis GDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 245-252 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kanellopoulos AJ Asimellis G Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
description	Anastasios John Kanellopoulos,1,2 George Asimellis11LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USAPurpose: To investigate repeatability of steep and flat keratometry measurements, as well as astigmatism axis in cohorts with normal range and regular astigmatic such as: eyes following laser-assisted in situ keratomileusis (LASIK) and normal population, as well as cohorts of high and irregular astigmatism such as keratoconic eyes, and keratoconic eyes following corneal collagen cross-linking, employing a novel corneal reflection topography device.Methods: Steep and flat keratometry and astigmatism axis measurement repeatability was investigated employing a novel multicolored-spot reflection topographer (Cassini) in four study groups, namely a post myopic LASIK-treated Group A, a keratoconus Group B, a post-CXL keratoconus Group C, and a control Group D of routine healthy patients. Three separate, maps were obtained employing the Cassini, enabling investigation of the intra-individual repeatability by standard deviation. Additionally we investigated in all groups,the Klyce surface irregularity indices for keratoconus, the SAI (surface asymmetry index) and the SRI (surface regularity index).Results: Flat keratometry repeatability was 0.74±0.89 (0.03 to 5.26) diopters (D) in the LASIK Group A, 0.88±1.45 (range minimum to maximum, 0.00 to 7.84) D in the keratoconic Group B, and 0.71±0.94 (0.02 to 6.23) D in the cross-linked Group C. The control Group D had flat keratometry repeatability 0.36±0.46 (0.00 to 2.71) D. Steep keratometry repeatability was 0.64±0.82 (0.01 to 4.81) D in the LASIK Group A, 0.89±1.22 (0.02 to 7.85) D in the keratoconic Group B, and 0.93±1.12 (0.04 to 5.93) D in the cross-linked Group C. The control Group D had steep keratometry repeatability 0.41±0.50 (0.00 to 3.51) D. Axis repeatability was 3.45±1.62° (0.38 to 7.78°) for the LASIK Group A, 4.12±3.17° (0.02 to 12.13°) for the keratoconic Group B, and 3.20±1.99° (0.17 to 8.61°) for the cross-linked Group C. The control Group D had axis repeatability 2.16±1.39° (0.05 to 5.86°). The SAI index measurement repeatability was 0.33±0.40 (0.01 to 2.31) in the post-LASIK Group A, 0.39±0.75 (0.00 to 7.15) in the keratoconic Group B, and 0.43±0.56 (0.05 to 3.50) in the keratoconus post-CXL Group C. The control group had SAI measurement repeatability of 0.26±0.30 (0.00 to 2.39). The SRI index repeatability was 0.22±0.17 (0.01 to 0.96) for post-LASIK Group A, 0.20±0.18 (0.00 to 1.07) in keratoconic Group B, and 0.13±0.09 (0.00 to 0.45) in the keratoconus post-CXL Group C. The control Group D had SRI measurement repeatability of 0.23±0.16 (0.00 to 0.75).Conclusion: This novel corneal topography device appears to offer very high specificity in estimating corneal keratometry and specific corneal irregularity indices, even in topographically challenging corneas such as LASIK treated, keratoconic, and cross-linked.Keywords: LED topography, point-source topography, VU topographer, axis of astigmatism, Cassini topographer, steep meridian, surface regularity index, surface asymmetry index, form factor
format	article
author	Kanellopoulos AJ Asimellis G
author_facet	Kanellopoulos AJ Asimellis G
author_sort	Kanellopoulos AJ
title	Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
title_short	Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
title_full	Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
title_fullStr	Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
title_full_unstemmed	Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
title_sort	color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/9a28f1c6d622477c8ae0e5aad77119aa
work_keys_str_mv	AT kanellopoulosaj colorlightemittingdiodereflectiontopographyvalidationofkeratometricrepeatabilityinalargesampleofwidecylindricalrangecorneas AT asimellisg colorlightemittingdiodereflectiontopographyvalidationofkeratometricrepeatabilityinalargesampleofwidecylindricalrangecorneas
_version_	1718400247148838912

Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas

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