Improving event-based progression analysis in glaucomatous visual fields

Abstract Glaucoma is a progressive optic neuropathy with characteristic changes to the optic nerve head and the visual field (VF). Detecting progression of VF damage with Standard Automated Perimetry (SAP) is of paramount importance for clinical care. One common approach to detecting progression is...

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Autores principales:	Chiara Rui, Giovanni Montesano, David P. Crabb, Paolo Brusini, Balwantray C. Chauhan, Luca M. Rossetti, Paolo Fogagnolo, Jean-Marie Giraud, Jean-Rémi Fenolland, Francesco Oddone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a29557cc96044b9a46ddd610fc9a7ed
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spelling	oai:doaj.org-article:9a29557cc96044b9a46ddd610fc9a7ed2021-12-02T19:06:42ZImproving event-based progression analysis in glaucomatous visual fields10.1038/s41598-021-95877-92045-2322https://doaj.org/article/9a29557cc96044b9a46ddd610fc9a7ed2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95877-9https://doaj.org/toc/2045-2322Abstract Glaucoma is a progressive optic neuropathy with characteristic changes to the optic nerve head and the visual field (VF). Detecting progression of VF damage with Standard Automated Perimetry (SAP) is of paramount importance for clinical care. One common approach to detecting progression is to compare each new VF test to a baseline SAP test (event analysis). This comparison is made difficult by the test–retest variability of SAP, which increases with the level of VF damage, and the limited range of measurement, meaning that damage cannot be assessed below a certain level. We performed a prospective international multi-centre data collection of SAP data on 90 eyes from 90 people with glaucoma and different levels of VF damage over a short period of time (6 tests in 60 days). Data were collected using a fundus tracked perimeter (Compass, CenterVue). We used these data (minus the first test) to develop an improved event analysis that accounts for both the change in variability with damage and the lower bound on the measurement imposed by SAP. Using simulations, we show that our approach is more sensitive compared to previously developed methods, especially in the case of advanced glaucoma, while retaining similar specificity.Chiara RuiGiovanni MontesanoDavid P. CrabbPaolo BrusiniBalwantray C. ChauhanLuca M. RossettiPaolo FogagnoloJean-Marie GiraudJean-Rémi FenollandFrancesco OddoneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiara Rui Giovanni Montesano David P. Crabb Paolo Brusini Balwantray C. Chauhan Luca M. Rossetti Paolo Fogagnolo Jean-Marie Giraud Jean-Rémi Fenolland Francesco Oddone Improving event-based progression analysis in glaucomatous visual fields
description	Abstract Glaucoma is a progressive optic neuropathy with characteristic changes to the optic nerve head and the visual field (VF). Detecting progression of VF damage with Standard Automated Perimetry (SAP) is of paramount importance for clinical care. One common approach to detecting progression is to compare each new VF test to a baseline SAP test (event analysis). This comparison is made difficult by the test–retest variability of SAP, which increases with the level of VF damage, and the limited range of measurement, meaning that damage cannot be assessed below a certain level. We performed a prospective international multi-centre data collection of SAP data on 90 eyes from 90 people with glaucoma and different levels of VF damage over a short period of time (6 tests in 60 days). Data were collected using a fundus tracked perimeter (Compass, CenterVue). We used these data (minus the first test) to develop an improved event analysis that accounts for both the change in variability with damage and the lower bound on the measurement imposed by SAP. Using simulations, we show that our approach is more sensitive compared to previously developed methods, especially in the case of advanced glaucoma, while retaining similar specificity.
format	article
author	Chiara Rui Giovanni Montesano David P. Crabb Paolo Brusini Balwantray C. Chauhan Luca M. Rossetti Paolo Fogagnolo Jean-Marie Giraud Jean-Rémi Fenolland Francesco Oddone
author_facet	Chiara Rui Giovanni Montesano David P. Crabb Paolo Brusini Balwantray C. Chauhan Luca M. Rossetti Paolo Fogagnolo Jean-Marie Giraud Jean-Rémi Fenolland Francesco Oddone
author_sort	Chiara Rui
title	Improving event-based progression analysis in glaucomatous visual fields
title_short	Improving event-based progression analysis in glaucomatous visual fields
title_full	Improving event-based progression analysis in glaucomatous visual fields
title_fullStr	Improving event-based progression analysis in glaucomatous visual fields
title_full_unstemmed	Improving event-based progression analysis in glaucomatous visual fields
title_sort	improving event-based progression analysis in glaucomatous visual fields
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9a29557cc96044b9a46ddd610fc9a7ed
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Improving event-based progression analysis in glaucomatous visual fields

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