Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions

DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks that impede the sliding complex Msh2-Msh6.

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Autores principales:	Maxwell W. Brown, Yoori Kim, Gregory M. Williams, John D. Huck, Jennifer A. Surtees, Ilya J. Finkelstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a3005080b6f41aa9f1b91e79f07cfd2
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spelling	oai:doaj.org-article:9a3005080b6f41aa9f1b91e79f07cfd22021-12-02T15:35:24ZDynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions10.1038/ncomms106072041-1723https://doaj.org/article/9a3005080b6f41aa9f1b91e79f07cfd22016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10607https://doaj.org/toc/2041-1723DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks that impede the sliding complex Msh2-Msh6.Maxwell W. BrownYoori KimGregory M. WilliamsJohn D. HuckJennifer A. SurteesIlya J. FinkelsteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maxwell W. Brown Yoori Kim Gregory M. Williams John D. Huck Jennifer A. Surtees Ilya J. Finkelstein Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
description	DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks that impede the sliding complex Msh2-Msh6.
format	article
author	Maxwell W. Brown Yoori Kim Gregory M. Williams John D. Huck Jennifer A. Surtees Ilya J. Finkelstein
author_facet	Maxwell W. Brown Yoori Kim Gregory M. Williams John D. Huck Jennifer A. Surtees Ilya J. Finkelstein
author_sort	Maxwell W. Brown
title	Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
title_short	Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
title_full	Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
title_fullStr	Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
title_full_unstemmed	Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
title_sort	dynamic dna binding licenses a repair factor to bypass roadblocks in search of dna lesions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9a3005080b6f41aa9f1b91e79f07cfd2
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Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions

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