THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1

Numerous modern basic research done undeniable fact that neutrophilic granulocytes (NG) are key effector and regulatory circuits both innate and adaptive immunity, and play a crucial role in the pathogenesis of a wide range of diseases. NG have potent receptor repertoire, providing a connection betw...

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Autores principales:	I. V. Nesterova, N. V. Kolesnikova, G. A. Chudilova, L. V. Lomtatidze, S. V. Kovaleva, A. A. Evglevsky, T.D. L. Nguyen
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	neutrophil granulocytes immunophenotype microbicide extracellular traps restructuring сhromatin cytokine production Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9a346b7b88d74940ada71f664858220b
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spelling	oai:doaj.org-article:9a346b7b88d74940ada71f664858220b2021-11-22T07:09:48ZTHE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 12220-76192313-739810.15789/2220-7619-2017-3-219-230https://doaj.org/article/9a346b7b88d74940ada71f664858220b2017-09-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/554https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Numerous modern basic research done undeniable fact that neutrophilic granulocytes (NG) are key effector and regulatory circuits both innate and adaptive immunity, and play a crucial role in the pathogenesis of a wide range of diseases. NG have potent receptor repertoire, providing a connection between them, cells of the immune system, as well as communication with endothelial cells, epithelial and other tissues. NG inducing stimuli activate and promote the translocation of cytoplasmic granules and vesicles surface molecules on the cytoplasmic membrane the secretion of a large spectrum of pro-and anti-inf lammatory, immunoregulatory cytokines, colony, angiogenic factors and fibrogenic, TNF superfamily members, chemokines, regulatory protein, etc. Chromatin nuclei NG capable of restructuring under the influence of inducing stimuli, which is associated with the expression of multiple cytokine genes. NG receiving complex cytokine inf luence not only acquire new features, but also in various stages of activation and differentiation processes involved in intracellular intraphagosomalis degranulation and killing of implementing elimination microorganisms and extracellular neutrophil degranulation in the formation neutrophil extracellular traps (NET), while this dying through NETosis. Features NG phenotype and their functional properties, demonstrate the existence of subpopulations of NG with different capabilities: equipment of different receptor, the ability to restructure chromatin expressing cytokine genes and secrete cytokines to implement the contents of the granular system, produce reactive oxygen species, implement cytotoxicity form NET. In our opinion, there subpopulation NG: regulatory; suppressor; proinf lammatory — initiating an inf lammatory response; inf lammation with a positive potential microbicidal (antibacterial, antiviral, antifungal); inf lammatory cytotoxic potential of the negative — “aggressive”; anti-inf lammation regulating regression; antitumoral — TAN1; pro-tumoral — TAN2; hybrid, combining the characteristics of NG and dendritic cells. The absence of adequate response, or hyperactivation blockade NG functions leads to the development of low-intensity infectious and inf lammatory diseases, do not respond to conventional therapy of autoimmune diseases/chronic immune-dependent processes. Remodeling dysfunctions NG — the key to new immunotherapeutic strategies.I. V. NesterovaN. V. KolesnikovaG. A. ChudilovaL. V. LomtatidzeS. V. KovalevaA. A. EvglevskyT.D. L. NguyenSankt-Peterburg : NIIÈM imeni Pasteraarticleneutrophil granulocytesimmunophenotypemicrobicideextracellular trapsrestructuring сhromatincytokine productionInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 7, Iss 3, Pp 219-230 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutrophil granulocytes immunophenotype microbicide extracellular traps restructuring сhromatin cytokine production Infectious and parasitic diseases RC109-216
spellingShingle	neutrophil granulocytes immunophenotype microbicide extracellular traps restructuring сhromatin cytokine production Infectious and parasitic diseases RC109-216 I. V. Nesterova N. V. Kolesnikova G. A. Chudilova L. V. Lomtatidze S. V. Kovaleva A. A. Evglevsky T.D. L. Nguyen THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
description	Numerous modern basic research done undeniable fact that neutrophilic granulocytes (NG) are key effector and regulatory circuits both innate and adaptive immunity, and play a crucial role in the pathogenesis of a wide range of diseases. NG have potent receptor repertoire, providing a connection between them, cells of the immune system, as well as communication with endothelial cells, epithelial and other tissues. NG inducing stimuli activate and promote the translocation of cytoplasmic granules and vesicles surface molecules on the cytoplasmic membrane the secretion of a large spectrum of pro-and anti-inf lammatory, immunoregulatory cytokines, colony, angiogenic factors and fibrogenic, TNF superfamily members, chemokines, regulatory protein, etc. Chromatin nuclei NG capable of restructuring under the influence of inducing stimuli, which is associated with the expression of multiple cytokine genes. NG receiving complex cytokine inf luence not only acquire new features, but also in various stages of activation and differentiation processes involved in intracellular intraphagosomalis degranulation and killing of implementing elimination microorganisms and extracellular neutrophil degranulation in the formation neutrophil extracellular traps (NET), while this dying through NETosis. Features NG phenotype and their functional properties, demonstrate the existence of subpopulations of NG with different capabilities: equipment of different receptor, the ability to restructure chromatin expressing cytokine genes and secrete cytokines to implement the contents of the granular system, produce reactive oxygen species, implement cytotoxicity form NET. In our opinion, there subpopulation NG: regulatory; suppressor; proinf lammatory — initiating an inf lammatory response; inf lammation with a positive potential microbicidal (antibacterial, antiviral, antifungal); inf lammatory cytotoxic potential of the negative — “aggressive”; anti-inf lammation regulating regression; antitumoral — TAN1; pro-tumoral — TAN2; hybrid, combining the characteristics of NG and dendritic cells. The absence of adequate response, or hyperactivation blockade NG functions leads to the development of low-intensity infectious and inf lammatory diseases, do not respond to conventional therapy of autoimmune diseases/chronic immune-dependent processes. Remodeling dysfunctions NG — the key to new immunotherapeutic strategies.
format	article
author	I. V. Nesterova N. V. Kolesnikova G. A. Chudilova L. V. Lomtatidze S. V. Kovaleva A. A. Evglevsky T.D. L. Nguyen
author_facet	I. V. Nesterova N. V. Kolesnikova G. A. Chudilova L. V. Lomtatidze S. V. Kovaleva A. A. Evglevsky T.D. L. Nguyen
author_sort	I. V. Nesterova
title	THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
title_short	THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
title_full	THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
title_fullStr	THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
title_full_unstemmed	THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
title_sort	new look at neutrophilic granulocytes: rethinking old dogmas. part 1
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/9a346b7b88d74940ada71f664858220b
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THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1

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