Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis

Objective To investigate the efficacy and safety of posaconazole (PCZ) in the prevention of invasive fungal disease (IFD) during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods The medical records of 80 patients who received allo-HSCT at our center from March 2017 to March 2...

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Autores principales:	ZHANG Yanfang, LOU Shifeng, CHEN Shu, ZHOU KangLUO Yun, LUO Yun, HUANG Xi
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Office of Journal of Third Military Medical University 2021
Materias:	posaconazole allogeneic hematopoietic stem cell transplantation invasive fungal infection prophylactic antifungal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9a353d3030f6441e8221d240721ecae5
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spelling	oai:doaj.org-article:9a353d3030f6441e8221d240721ecae52021-11-12T04:40:47ZEfficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis10.16016/j.1000-5404.2021080621000-5404https://doaj.org/article/9a353d3030f6441e8221d240721ecae52021-11-01T00:00:00Zhttp://aammt.tmmu.edu.cn/Upload/rhtml/202108062.htmhttps://doaj.org/toc/1000-5404 Objective To investigate the efficacy and safety of posaconazole (PCZ) in the prevention of invasive fungal disease (IFD) during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods The medical records of 80 patients who received allo-HSCT at our center from March 2017 to March 2021 were retrospectively reviewed and analyzed. They were accordingly divided into PCZ group (n=50) and control group (n=30, taking other anti-fungal drugs). The efficacy and safety of PCZ was analyzed in the prevention of IFD. Results In the PCZ group, 6 patients (12.0%) developed IFD, including 2 confirmed cases and 4 clinically diagnosed. While, IFD occurred in 14 cases from the control group, including 6 confirmed, 6 clinically diagnosed and 2 suspected cases. The incidence of IFD was significantly lower in the PCZ group than the control group (P=0.001). Moreover, in the PCZ group, 38 patients (10.5%) with primary prevention developed 4 cases of IFD, and 2 cases (16.7%) of IFD occurred in 12 patients of secondary prevention, showing no significant difference in the IFD incidence (P=0.951). The IFD-related mortality (21.0% vs 61.5%, P=0.030) and rate of abnormal liver function (20.0% vs 46.7%, P=0.012) were both significantly lower in the PCZ group than the control group. Conclusion PCZ is effective in the prevention of IFD during allo-HSCT, and reduces IFD-related deaths and occurrence of adverse reactions.ZHANG YanfangLOU ShifengCHEN ShuZHOU KangLUO YunLUO YunHUANG XiEditorial Office of Journal of Third Military Medical Universityarticleposaconazoleallogeneic hematopoietic stem cell transplantationinvasive fungal infectionprophylactic antifungal therapyMedicine (General)R5-920ZHDi-san junyi daxue xuebao, Vol 43, Iss 21, Pp 2307-2312 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	posaconazole allogeneic hematopoietic stem cell transplantation invasive fungal infection prophylactic antifungal therapy Medicine (General) R5-920
spellingShingle	posaconazole allogeneic hematopoietic stem cell transplantation invasive fungal infection prophylactic antifungal therapy Medicine (General) R5-920 ZHANG Yanfang LOU Shifeng CHEN Shu ZHOU KangLUO Yun LUO Yun HUANG Xi Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
description	Objective To investigate the efficacy and safety of posaconazole (PCZ) in the prevention of invasive fungal disease (IFD) during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods The medical records of 80 patients who received allo-HSCT at our center from March 2017 to March 2021 were retrospectively reviewed and analyzed. They were accordingly divided into PCZ group (n=50) and control group (n=30, taking other anti-fungal drugs). The efficacy and safety of PCZ was analyzed in the prevention of IFD. Results In the PCZ group, 6 patients (12.0%) developed IFD, including 2 confirmed cases and 4 clinically diagnosed. While, IFD occurred in 14 cases from the control group, including 6 confirmed, 6 clinically diagnosed and 2 suspected cases. The incidence of IFD was significantly lower in the PCZ group than the control group (P=0.001). Moreover, in the PCZ group, 38 patients (10.5%) with primary prevention developed 4 cases of IFD, and 2 cases (16.7%) of IFD occurred in 12 patients of secondary prevention, showing no significant difference in the IFD incidence (P=0.951). The IFD-related mortality (21.0% vs 61.5%, P=0.030) and rate of abnormal liver function (20.0% vs 46.7%, P=0.012) were both significantly lower in the PCZ group than the control group. Conclusion PCZ is effective in the prevention of IFD during allo-HSCT, and reduces IFD-related deaths and occurrence of adverse reactions.
format	article
author	ZHANG Yanfang LOU Shifeng CHEN Shu ZHOU KangLUO Yun LUO Yun HUANG Xi
author_facet	ZHANG Yanfang LOU Shifeng CHEN Shu ZHOU KangLUO Yun LUO Yun HUANG Xi
author_sort	ZHANG Yanfang
title	Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
title_short	Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
title_full	Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
title_fullStr	Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
title_full_unstemmed	Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
title_sort	efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis
publisher	Editorial Office of Journal of Third Military Medical University
publishDate	2021
url	https://doaj.org/article/9a353d3030f6441e8221d240721ecae5
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Efficacy and safety of posaconazole in prevention of invasive fungal infections during allogeneic hematopoietic stem cell transplantation: a single-center retrospective analysis

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