Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance

ABSTRACT The landscape of infectious fungal agents includes previously unidentified or rare pathogens with the potential to cause unprecedented casualties in biodiversity, food security, and human health. The influences of human activity, including the crisis of climate change, along with globalized...

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Autores principales:	B. Ball, M. Langille, J. Geddes-McAlister
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	omics technologies emerging fungal pathogens fungal pathogenesis antifungal resistance data integration genomics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9a3609e5ff0b4eb786355143634e41e1
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spelling	oai:doaj.org-article:9a3609e5ff0b4eb786355143634e41e12021-11-15T16:19:10ZFun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance10.1128/mBio.01020-202150-7511https://doaj.org/article/9a3609e5ff0b4eb786355143634e41e12020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01020-20https://doaj.org/toc/2150-7511ABSTRACT The landscape of infectious fungal agents includes previously unidentified or rare pathogens with the potential to cause unprecedented casualties in biodiversity, food security, and human health. The influences of human activity, including the crisis of climate change, along with globalized transport, are underlying factors shaping fungal adaptation to increased temperature and expanded geographical regions. Furthermore, the emergence of novel antifungal-resistant strains linked to excessive use of antifungals (in the clinic) and fungicides (in the field) offers an additional challenge to protect major crop staples and control dangerous fungal outbreaks. Hence, the alarming frequency of fungal infections in medical and agricultural settings requires effective research to understand the virulent nature of fungal pathogens and improve the outcome of infection in susceptible hosts. Mycology-driven research has benefited from a contemporary and unified approach of omics technology, deepening the biological, biochemical, and biophysical understanding of these emerging fungal pathogens. Here, we review the current state-of-the-art multi-omics technologies, explore the power of data integration strategies, and highlight discovery-based revelations of globally important and taxonomically diverse fungal pathogens. This information provides new insight for emerging pathogens through an in-depth understanding of well-characterized fungi and provides alternative therapeutic strategies defined through novel findings of virulence, adaptation, and resistance.B. BallM. LangilleJ. Geddes-McAlisterAmerican Society for Microbiologyarticleomics technologiesemerging fungal pathogensfungal pathogenesisantifungal resistancedata integrationgenomicsMicrobiologyQR1-502ENmBio, Vol 11, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	omics technologies emerging fungal pathogens fungal pathogenesis antifungal resistance data integration genomics Microbiology QR1-502
spellingShingle	omics technologies emerging fungal pathogens fungal pathogenesis antifungal resistance data integration genomics Microbiology QR1-502 B. Ball M. Langille J. Geddes-McAlister Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
description	ABSTRACT The landscape of infectious fungal agents includes previously unidentified or rare pathogens with the potential to cause unprecedented casualties in biodiversity, food security, and human health. The influences of human activity, including the crisis of climate change, along with globalized transport, are underlying factors shaping fungal adaptation to increased temperature and expanded geographical regions. Furthermore, the emergence of novel antifungal-resistant strains linked to excessive use of antifungals (in the clinic) and fungicides (in the field) offers an additional challenge to protect major crop staples and control dangerous fungal outbreaks. Hence, the alarming frequency of fungal infections in medical and agricultural settings requires effective research to understand the virulent nature of fungal pathogens and improve the outcome of infection in susceptible hosts. Mycology-driven research has benefited from a contemporary and unified approach of omics technology, deepening the biological, biochemical, and biophysical understanding of these emerging fungal pathogens. Here, we review the current state-of-the-art multi-omics technologies, explore the power of data integration strategies, and highlight discovery-based revelations of globally important and taxonomically diverse fungal pathogens. This information provides new insight for emerging pathogens through an in-depth understanding of well-characterized fungi and provides alternative therapeutic strategies defined through novel findings of virulence, adaptation, and resistance.
format	article
author	B. Ball M. Langille J. Geddes-McAlister
author_facet	B. Ball M. Langille J. Geddes-McAlister
author_sort	B. Ball
title	Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
title_short	Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
title_full	Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
title_fullStr	Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
title_full_unstemmed	Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
title_sort	fun(gi)omics: advanced and diverse technologies to explore emerging fungal pathogens and define mechanisms of antifungal resistance
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/9a3609e5ff0b4eb786355143634e41e1
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Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance

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