PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin

Abstract Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion prot...

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Autores principales:	Xiao Miao, Rong Xu, Bin Fan, Jie Chen, Xin Li, Weiwei Mao, Shengyuan Hua, Bin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a36396010b7476e9528450dad41d074
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spelling	oai:doaj.org-article:9a36396010b7476e9528450dad41d0742021-12-02T15:08:12ZPD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin10.1038/s41598-018-19407-w2045-2322https://doaj.org/article/9a36396010b7476e9528450dad41d0742018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19407-whttps://doaj.org/toc/2045-2322Abstract Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion protein. Treatment with this fusion protein significantly reversed/suppressed depigmentation development in adult Pmel-1 mice. Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice. Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice.Xiao MiaoRong XuBin FanJie ChenXin LiWeiwei MaoShengyuan HuaBin LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiao Miao Rong Xu Bin Fan Jie Chen Xin Li Weiwei Mao Shengyuan Hua Bin Li PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
description	Abstract Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion protein. Treatment with this fusion protein significantly reversed/suppressed depigmentation development in adult Pmel-1 mice. Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice. Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice.
format	article
author	Xiao Miao Rong Xu Bin Fan Jie Chen Xin Li Weiwei Mao Shengyuan Hua Bin Li
author_facet	Xiao Miao Rong Xu Bin Fan Jie Chen Xin Li Weiwei Mao Shengyuan Hua Bin Li
author_sort	Xiao Miao
title	PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
title_short	PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
title_full	PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
title_fullStr	PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
title_full_unstemmed	PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
title_sort	pd-l1 reverses depigmentation in pmel-1 vitiligo mice by increasing the abundance of tregs in the skin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9a36396010b7476e9528450dad41d074
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PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin

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