In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation

A novel approach is presented for the non-invasive quantification of axial displacement and strain in corneal and anterior crystalline lens tissue in response to a homogenous ambient pressure change. A spectral domain optical coherence tomography (OCT) system was combined with a custom-built set of...

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Autor principal:	Sabine Kling
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	corneal biomechanics optical coherence tomography ambient pressure modulation in vivo ocular imaging Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/9a367db975784fa7bcb7c8526f2ae758
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spelling	oai:doaj.org-article:9a367db975784fa7bcb7c8526f2ae7582021-11-15T06:08:43ZIn-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation2296-418510.3389/fbioe.2021.759588https://doaj.org/article/9a367db975784fa7bcb7c8526f2ae7582021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.759588/fullhttps://doaj.org/toc/2296-4185A novel approach is presented for the non-invasive quantification of axial displacement and strain in corneal and anterior crystalline lens tissue in response to a homogenous ambient pressure change. A spectral domain optical coherence tomography (OCT) system was combined with a custom-built set of swimming goggles and a pressure control unit to acquire repetitive cross-sectional scans of the anterior ocular segment before, during and after ambient pressure modulation. The potential of the technique is demonstrated in vivo in a healthy human subject. The quantification of the dynamic deformation response, consisting of axial displacement and strain, demonstrated an initial retraction of the eye globe (−0.43 to −1.22 nm) and a subsequent forward motion (1.99 nm) in response to the pressure change, which went along with a compressive strain induced in the anterior crystalline lens (−0.009) and a tensile strain induced in the cornea (0.014). These mechanical responses appear to be the result of a combination of whole eye motion and eye globe expansion. The latter simulates a close-to-physiologic variation of the intraocular pressure and makes the detected mechanical responses potentially relevant for clinical follow-up and pre-surgical screening. The presented measurements are a proof-of-concept that non-contact low-amplitude ambient pressure modulation induces tissue displacement and strain that is detectable in vivo with OCT. To take full advantage of the high spatial resolution this imaging technique could offer, further software and hardware optimization will be necessary to overcome the current limitation of involuntary eye motions.Sabine KlingFrontiers Media S.A.articlecorneal biomechanicsoptical coherence tomographyambient pressure modulationin vivoocular imagingBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal biomechanics optical coherence tomography ambient pressure modulation in vivo ocular imaging Biotechnology TP248.13-248.65
spellingShingle	corneal biomechanics optical coherence tomography ambient pressure modulation in vivo ocular imaging Biotechnology TP248.13-248.65 Sabine Kling In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
description	A novel approach is presented for the non-invasive quantification of axial displacement and strain in corneal and anterior crystalline lens tissue in response to a homogenous ambient pressure change. A spectral domain optical coherence tomography (OCT) system was combined with a custom-built set of swimming goggles and a pressure control unit to acquire repetitive cross-sectional scans of the anterior ocular segment before, during and after ambient pressure modulation. The potential of the technique is demonstrated in vivo in a healthy human subject. The quantification of the dynamic deformation response, consisting of axial displacement and strain, demonstrated an initial retraction of the eye globe (−0.43 to −1.22 nm) and a subsequent forward motion (1.99 nm) in response to the pressure change, which went along with a compressive strain induced in the anterior crystalline lens (−0.009) and a tensile strain induced in the cornea (0.014). These mechanical responses appear to be the result of a combination of whole eye motion and eye globe expansion. The latter simulates a close-to-physiologic variation of the intraocular pressure and makes the detected mechanical responses potentially relevant for clinical follow-up and pre-surgical screening. The presented measurements are a proof-of-concept that non-contact low-amplitude ambient pressure modulation induces tissue displacement and strain that is detectable in vivo with OCT. To take full advantage of the high spatial resolution this imaging technique could offer, further software and hardware optimization will be necessary to overcome the current limitation of involuntary eye motions.
format	article
author	Sabine Kling
author_facet	Sabine Kling
author_sort	Sabine Kling
title	In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
title_short	In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
title_full	In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
title_fullStr	In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
title_full_unstemmed	In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation
title_sort	in-vivo measurement of ocular deformation in response to ambient pressure modulation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9a367db975784fa7bcb7c8526f2ae758
work_keys_str_mv	AT sabinekling invivomeasurementofoculardeformationinresponsetoambientpressuremodulation
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In-Vivo Measurement of Ocular Deformation in Response to Ambient Pressure Modulation

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