Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice

Purpose Exercise is a representative noninvasive treatment that can be applied to various diseases. We studied the effect of resistance exercise on motor function and spatial learning ability in Parkinson disease (PD) mice. Methods The rotarod test and beam walking test were conducted to evaluate th...

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Autores principales:	Sang-Hoon Kim, Lakkyong Hwang, Jun-Jang Jin, Il-Gyu Ko, Yong Bog Kim, Hye-Sun Yoon, Seung-Soo Baek
Formato:	article
Lenguaje:	EN
Publicado:	Korean Continence Society 2021
Materias:	resistance exercise parkinson disease spatial learning ability brain-derived neurotrophic factor 5’-adenosine monophosphate-activated protein kinase Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/9a3c02295c8e44c48eede0126d26c6d7
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spelling	oai:doaj.org-article:9a3c02295c8e44c48eede0126d26c6d72021-11-30T04:10:47ZResistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice2093-47772093-693110.5213/inj.2142336.168https://doaj.org/article/9a3c02295c8e44c48eede0126d26c6d72021-11-01T00:00:00Zhttp://www.einj.org/upload/pdf/inj-2142336-168.pdfhttps://doaj.org/toc/2093-4777https://doaj.org/toc/2093-6931Purpose Exercise is a representative noninvasive treatment that can be applied to various diseases. We studied the effect of resistance exercise on motor function and spatial learning ability in Parkinson disease (PD) mice. Methods The rotarod test and beam walking test were conducted to evaluate the effect of resistance exercise on motor function, and the Morris water maze test was conducted to examine the effect of resistance exercise on spatial learning ability. The effect of resistance exercise on brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) expression and 5’-adenosine monophosphate-activated protein kinase (AMPK) phosphorylation was investigated by Western blot analysis. New cell generation was confirmed by immunohistochemistry for 5-bromo-2’-deoxyuridine. Results Resistance exercise improved coordination, balance, and spatial learning ability in PD mice. Resistance exercise enhanced new cell production, BDNF and TrkB expression, and AMPK phosphorylation in PD mice. The effect of such resistance exercise was similar to that of levodopa application. Conclusions In PD-induced mice, resistance exercise enhanced AMPK phosphorylation to increase BDNF expression and new neuron generation, thereby improving spatial learning ability. Resistance exercise is believed to help improve symptoms of PD.Sang-Hoon KimLakkyong HwangJun-Jang JinIl-Gyu KoYong Bog KimHye-Sun YoonSeung-Soo BaekKorean Continence Societyarticleresistance exerciseparkinson diseasespatial learning abilitybrain-derived neurotrophic factor5’-adenosine monophosphate-activated protein kinaseDiseases of the genitourinary system. UrologyRC870-923ENInternational Neurourology Journal, Vol 25, Iss Suppl 2, Pp S55-62 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resistance exercise parkinson disease spatial learning ability brain-derived neurotrophic factor 5’-adenosine monophosphate-activated protein kinase Diseases of the genitourinary system. Urology RC870-923
spellingShingle	resistance exercise parkinson disease spatial learning ability brain-derived neurotrophic factor 5’-adenosine monophosphate-activated protein kinase Diseases of the genitourinary system. Urology RC870-923 Sang-Hoon Kim Lakkyong Hwang Jun-Jang Jin Il-Gyu Ko Yong Bog Kim Hye-Sun Yoon Seung-Soo Baek Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
description	Purpose Exercise is a representative noninvasive treatment that can be applied to various diseases. We studied the effect of resistance exercise on motor function and spatial learning ability in Parkinson disease (PD) mice. Methods The rotarod test and beam walking test were conducted to evaluate the effect of resistance exercise on motor function, and the Morris water maze test was conducted to examine the effect of resistance exercise on spatial learning ability. The effect of resistance exercise on brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) expression and 5’-adenosine monophosphate-activated protein kinase (AMPK) phosphorylation was investigated by Western blot analysis. New cell generation was confirmed by immunohistochemistry for 5-bromo-2’-deoxyuridine. Results Resistance exercise improved coordination, balance, and spatial learning ability in PD mice. Resistance exercise enhanced new cell production, BDNF and TrkB expression, and AMPK phosphorylation in PD mice. The effect of such resistance exercise was similar to that of levodopa application. Conclusions In PD-induced mice, resistance exercise enhanced AMPK phosphorylation to increase BDNF expression and new neuron generation, thereby improving spatial learning ability. Resistance exercise is believed to help improve symptoms of PD.
format	article
author	Sang-Hoon Kim Lakkyong Hwang Jun-Jang Jin Il-Gyu Ko Yong Bog Kim Hye-Sun Yoon Seung-Soo Baek
author_facet	Sang-Hoon Kim Lakkyong Hwang Jun-Jang Jin Il-Gyu Ko Yong Bog Kim Hye-Sun Yoon Seung-Soo Baek
author_sort	Sang-Hoon Kim
title	Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
title_short	Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
title_full	Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
title_fullStr	Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
title_full_unstemmed	Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
title_sort	resistance exercise improves spatial learning ability through phosphorylation of 5’-adenosine monophosphate-activated protein kinase in parkinson disease mice
publisher	Korean Continence Society
publishDate	2021
url	https://doaj.org/article/9a3c02295c8e44c48eede0126d26c6d7
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Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice

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