Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management

Jyotindra Narayan Goswami,1 Suvasini Sharma2 1Department of Pediatrics, Army Hospital (Research & Referral), New Delhi 110010, India; 2Neurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children’s Hospital, New Delhi 110001, In...

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Autores principales:	Goswami JN, Sharma S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	modified atkins diet low glycemic index diet ketosis intractable epilepsy epileptic encephalopathies. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9a3cf15265c54a008cbeb79ab0dd2d33
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spelling	oai:doaj.org-article:9a3cf15265c54a008cbeb79ab0dd2d332021-12-02T05:26:20ZCurrent Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management1178-2021https://doaj.org/article/9a3cf15265c54a008cbeb79ab0dd2d332019-11-01T00:00:00Zhttps://www.dovepress.com/current-perspectives-on-the-role-of-the-ketogenic-diet-in-epilepsy-man-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jyotindra Narayan Goswami,1 Suvasini Sharma2 1Department of Pediatrics, Army Hospital (Research & Referral), New Delhi 110010, India; 2Neurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children’s Hospital, New Delhi 110001, IndiaCorrespondence: Suvasini SharmaNeurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children’s Hospital, Connaught Place 110001, New Delhi Tel +91-9910234344Email sharma.suvasini@gmail.comAbstract: Drug-refractory epilepsy is a commonly prevalent pediatric neurological illness of global significance. Ketogenic diet (KD) is a time-tested therapeutic modality for refractory epilepsy, which has reemerged as a robust alternative to anti-epileptic pharmacotherapy. There is a growing body of evidence which supports the anti-seizure efficacy, safety profile and feasibility of KD use in childhood epilepsy. In addition, this modality has been recognized to reduce anti-epileptic exposure, improve cognition and behavioral profile of patients as well as improve the quality-of-life of care-givers. Current indications of KD include refractory epilepsy syndromes, selected metabolic disorders (such as pyruvate dehydrogenase deficiency) and a host of varied neurological entities. KD research has broadened the knowledge-base about its mechanisms of action. Four types of KD are in vogue currently with varying nutritional constitution, palatability, administration protocols and comparable efficacy. KD initiation and maintenance are the result of concerted effort of a team of pediatric neurologist/epileptologist, nutritionist and patient’s primary care-giver. Consensus is being formulated about various practical aspects of KD such as patient-selection, parental counseling, baseline work-up, dietary prescription, nutritional supplementation, concurrent anti-epileptic drug administration, follow-up and treatment-duration. Novel applications of KD include its use in neonatal epilepsy and super-refractory status epilepticus and tailor-made formulations such as cooking oil-based KD in predominantly rice-fed populations. Increasing body of clinical experience, improved nutritional designs and translational research are promoting KD as a major therapeutic modality. Currently, KD forms a core essence in the armamentarium against refractory epilepsy. In this review, we summarize the recent advances and current perspectives in the use of KD in refractory epilepsy.Keywords: Modified Atkins Diet, low glycemic index diet, ketosis, intractable epilepsy, epileptic encephalopathies, ketogenic diet, epilepsyGoswami JNSharma SDove Medical Pressarticlemodified atkins dietlow glycemic index dietketosisintractable epilepsyepileptic encephalopathies.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3273-3285 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	modified atkins diet low glycemic index diet ketosis intractable epilepsy epileptic encephalopathies. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	modified atkins diet low glycemic index diet ketosis intractable epilepsy epileptic encephalopathies. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Goswami JN Sharma S Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management
description	Jyotindra Narayan Goswami,1 Suvasini Sharma2 1Department of Pediatrics, Army Hospital (Research & Referral), New Delhi 110010, India; 2Neurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children’s Hospital, New Delhi 110001, IndiaCorrespondence: Suvasini SharmaNeurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children’s Hospital, Connaught Place 110001, New Delhi Tel +91-9910234344Email sharma.suvasini@gmail.comAbstract: Drug-refractory epilepsy is a commonly prevalent pediatric neurological illness of global significance. Ketogenic diet (KD) is a time-tested therapeutic modality for refractory epilepsy, which has reemerged as a robust alternative to anti-epileptic pharmacotherapy. There is a growing body of evidence which supports the anti-seizure efficacy, safety profile and feasibility of KD use in childhood epilepsy. In addition, this modality has been recognized to reduce anti-epileptic exposure, improve cognition and behavioral profile of patients as well as improve the quality-of-life of care-givers. Current indications of KD include refractory epilepsy syndromes, selected metabolic disorders (such as pyruvate dehydrogenase deficiency) and a host of varied neurological entities. KD research has broadened the knowledge-base about its mechanisms of action. Four types of KD are in vogue currently with varying nutritional constitution, palatability, administration protocols and comparable efficacy. KD initiation and maintenance are the result of concerted effort of a team of pediatric neurologist/epileptologist, nutritionist and patient’s primary care-giver. Consensus is being formulated about various practical aspects of KD such as patient-selection, parental counseling, baseline work-up, dietary prescription, nutritional supplementation, concurrent anti-epileptic drug administration, follow-up and treatment-duration. Novel applications of KD include its use in neonatal epilepsy and super-refractory status epilepticus and tailor-made formulations such as cooking oil-based KD in predominantly rice-fed populations. Increasing body of clinical experience, improved nutritional designs and translational research are promoting KD as a major therapeutic modality. Currently, KD forms a core essence in the armamentarium against refractory epilepsy. In this review, we summarize the recent advances and current perspectives in the use of KD in refractory epilepsy.Keywords: Modified Atkins Diet, low glycemic index diet, ketosis, intractable epilepsy, epileptic encephalopathies, ketogenic diet, epilepsy
format	article
author	Goswami JN Sharma S
author_facet	Goswami JN Sharma S
author_sort	Goswami JN
title	Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management
title_short	Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management
title_full	Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management
title_fullStr	Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management
title_full_unstemmed	Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management
title_sort	current perspectives on the role of the ketogenic diet in epilepsy management
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9a3cf15265c54a008cbeb79ab0dd2d33
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Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management

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