A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis

Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting balanced antagonism between RhoA (stop-signal) and...

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Autores principales: Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri, Alan T. Nurden, Harald Schulze, Ute Modlich, Irina Pleines, Cord Brakebusch, Bernhard Nieswandt
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe
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spelling oai:doaj.org-article:9a41c7db2ef649429ea7c2db2ddf72fe2021-12-02T17:01:21ZA Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis10.1038/ncomms158382041-1723https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15838https://doaj.org/toc/2041-1723Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting balanced antagonism between RhoA (stop-signal) and Cdc42 (go-signal).Sebastian DüttingFrederique Gaits-IacovoniDavid StegnerMichael PoppAdrien AntkowiakJudith M.M. van EeuwijkPaquita NurdenSimon StrittTobias HeibKatja AurbachOguzhan AngayDeya CherpokovaNiels HeinzAyesha A. BaigMaximilian G. GorelashviliFrank GernerKatrin G. HeinzeJerry WareGeorg KrohneZaverio M. RuggeriAlan T. NurdenHarald SchulzeUte ModlichIrina PleinesCord BrakebuschBernhard NieswandtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sebastian Dütting
Frederique Gaits-Iacovoni
David Stegner
Michael Popp
Adrien Antkowiak
Judith M.M. van Eeuwijk
Paquita Nurden
Simon Stritt
Tobias Heib
Katja Aurbach
Oguzhan Angay
Deya Cherpokova
Niels Heinz
Ayesha A. Baig
Maximilian G. Gorelashvili
Frank Gerner
Katrin G. Heinze
Jerry Ware
Georg Krohne
Zaverio M. Ruggeri
Alan T. Nurden
Harald Schulze
Ute Modlich
Irina Pleines
Cord Brakebusch
Bernhard Nieswandt
A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
description Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting balanced antagonism between RhoA (stop-signal) and Cdc42 (go-signal).
format article
author Sebastian Dütting
Frederique Gaits-Iacovoni
David Stegner
Michael Popp
Adrien Antkowiak
Judith M.M. van Eeuwijk
Paquita Nurden
Simon Stritt
Tobias Heib
Katja Aurbach
Oguzhan Angay
Deya Cherpokova
Niels Heinz
Ayesha A. Baig
Maximilian G. Gorelashvili
Frank Gerner
Katrin G. Heinze
Jerry Ware
Georg Krohne
Zaverio M. Ruggeri
Alan T. Nurden
Harald Schulze
Ute Modlich
Irina Pleines
Cord Brakebusch
Bernhard Nieswandt
author_facet Sebastian Dütting
Frederique Gaits-Iacovoni
David Stegner
Michael Popp
Adrien Antkowiak
Judith M.M. van Eeuwijk
Paquita Nurden
Simon Stritt
Tobias Heib
Katja Aurbach
Oguzhan Angay
Deya Cherpokova
Niels Heinz
Ayesha A. Baig
Maximilian G. Gorelashvili
Frank Gerner
Katrin G. Heinze
Jerry Ware
Georg Krohne
Zaverio M. Ruggeri
Alan T. Nurden
Harald Schulze
Ute Modlich
Irina Pleines
Cord Brakebusch
Bernhard Nieswandt
author_sort Sebastian Dütting
title A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
title_short A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
title_full A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
title_fullStr A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
title_full_unstemmed A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
title_sort cdc42/rhoa regulatory circuit downstream of glycoprotein ib guides transendothelial platelet biogenesis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe
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