Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and Senescence

Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and Senescence

Human hepatocellular carcinoma (HCC) is among the most lethal and common cancers in the human population, and new molecular targets for therapeutic intervention are urgently needed. Deleted in liver cancer 1 (DLC1) was originally identified as a tumor suppressor gene in human HCC. DLC1 is a Rho-GTPa...

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Bibliographic Details
Main Authors: Laura Schreyer, Constanze Mittermeier, Miriam J. Franz, Melanie A. Meier, Dietmar E. Martin, Kerstin C. Maier, Kerstin Huebner, Regine Schneider-Stock, Stephan Singer, Kerstin Holzer, Dagmar Fischer, Silvia Ribback, Bernhard Liebl, Thomas Gudermann, Achim Aigner, Susanne Muehlich
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
DLC1
TSPAN5
MKL1
MRTF
SRF
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/9a46f0305c3f4da6928cc0db1f054c25
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https://doaj.org/article/9a46f0305c3f4da6928cc0db1f054c25

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