Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway ca...

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Autores principales:	Anand Patwardhan, Sabine Bardin, Stéphanie Miserey-Lenkei, Lionel Larue, Bruno Goud, Graça Raposo, Cédric Delevoye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a4a603bbe044a5f8583d0dd1c660ae5
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spelling	oai:doaj.org-article:9a4a603bbe044a5f8583d0dd1c660ae52021-12-02T15:39:01ZRouting of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes10.1038/ncomms158352041-1723https://doaj.org/article/9a4a603bbe044a5f8583d0dd1c660ae52017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15835https://doaj.org/toc/2041-1723The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.Anand PatwardhanSabine BardinStéphanie Miserey-LenkeiLionel LarueBruno GoudGraça RaposoCédric DelevoyeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anand Patwardhan Sabine Bardin Stéphanie Miserey-Lenkei Lionel Larue Bruno Goud Graça Raposo Cédric Delevoye Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
description	The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.
format	article
author	Anand Patwardhan Sabine Bardin Stéphanie Miserey-Lenkei Lionel Larue Bruno Goud Graça Raposo Cédric Delevoye
author_facet	Anand Patwardhan Sabine Bardin Stéphanie Miserey-Lenkei Lionel Larue Bruno Goud Graça Raposo Cédric Delevoye
author_sort	Anand Patwardhan
title	Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
title_short	Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
title_full	Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
title_fullStr	Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
title_full_unstemmed	Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
title_sort	routing of the rab6 secretory pathway towards the lysosome related organelle of melanocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9a4a603bbe044a5f8583d0dd1c660ae5
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Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

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