Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid

Masato Matsuoka,1 Hideyuki Yoshida,1 Yuichi Kinoshita,2 Tetsuya Nishimura11Department of Ophthalmology, 2Department of Histopathology, Kansai Medical University, Takii Hospital, Osaka, JapanPurpose: Intraocular lymphomas are rare, and they have poor prognosis. Thus, early diagnosis and treatment are...

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Autores principales:	Matsuoka M, Yoshida H, Kinoshita Y, Nishimura T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9a4bf403b03544c3928fb7a3e5506db4
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spelling	oai:doaj.org-article:9a4bf403b03544c3928fb7a3e5506db42021-12-02T04:49:12ZTwo cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid1177-54671177-5483https://doaj.org/article/9a4bf403b03544c3928fb7a3e5506db42013-04-01T00:00:00Zhttp://www.dovepress.com/two-cases-of-intraocular-lymphoma-diagnosed-by-analyses-of-vitreous-an-a12663https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Masato Matsuoka,1 Hideyuki Yoshida,1 Yuichi Kinoshita,2 Tetsuya Nishimura11Department of Ophthalmology, 2Department of Histopathology, Kansai Medical University, Takii Hospital, Osaka, JapanPurpose: Intraocular lymphomas are rare, and they have poor prognosis. Thus, early diagnosis and treatment are needed. A definitive diagnosis of a lymphoma is based on cytological analysis of the intraocular fluids or tissues. We report two cases of intraocular lymphoma diagnosed by the analyses of vitreous and infusion fluid.Patients: Case 1 was a 66-year-old woman who complained of eye floaters and was found to have diffuse vitreous opacification bilaterally. She received corticosteroid therapy, however the vitreous opacification was not resolved, and her visual acuity (VA) remained reduced. She underwent pars plana vitrectomy (PPV), and vitreous and infusion fluid were collected to determine the cause of the reduced VA. The undiluted vitreous obtained from core PPV was submitted for cytokine analysis, and infusion fluid was obtained from the machine cassette after full PPV and used for cytological analysis. Case 2 was a 62-year-old man referred with low vision and was found to have diffuse vitreous opacification in the right eye and dot hemorrhages in both eyes. Four years earlier, he had been diagnosed with diffuse large B-cell lymphoma of the paranasal sinuses and was in remission after chemotherapy. Because metastasis of the lymphoma was suspected, he underwent PPV, and intraocular samples were collected as in Case 1.Results: Atypical lymphoid cells were detected from the infusion fluid in both cases. The ratio of interleukin (IL)-10 to IL-6 was greater than 1.0 in both cases. These results allowed us to make a diagnosis of intraocular lymphoma: primary intraocular lymphoma in Case 1 and metastatic intraocular lymphoma in Case 2.Conclusion: Vitreous and infusion fluid collected during PPV can be used for diagnosing an intraocular lymphoma.Keywords: intraocular lymphoma, cytological analysis, vitreous, pars plana vitrectomy, infusion fluidMatsuoka MYoshida HKinoshita YNishimura TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 691-694 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Matsuoka M Yoshida H Kinoshita Y Nishimura T Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
description	Masato Matsuoka,1 Hideyuki Yoshida,1 Yuichi Kinoshita,2 Tetsuya Nishimura11Department of Ophthalmology, 2Department of Histopathology, Kansai Medical University, Takii Hospital, Osaka, JapanPurpose: Intraocular lymphomas are rare, and they have poor prognosis. Thus, early diagnosis and treatment are needed. A definitive diagnosis of a lymphoma is based on cytological analysis of the intraocular fluids or tissues. We report two cases of intraocular lymphoma diagnosed by the analyses of vitreous and infusion fluid.Patients: Case 1 was a 66-year-old woman who complained of eye floaters and was found to have diffuse vitreous opacification bilaterally. She received corticosteroid therapy, however the vitreous opacification was not resolved, and her visual acuity (VA) remained reduced. She underwent pars plana vitrectomy (PPV), and vitreous and infusion fluid were collected to determine the cause of the reduced VA. The undiluted vitreous obtained from core PPV was submitted for cytokine analysis, and infusion fluid was obtained from the machine cassette after full PPV and used for cytological analysis. Case 2 was a 62-year-old man referred with low vision and was found to have diffuse vitreous opacification in the right eye and dot hemorrhages in both eyes. Four years earlier, he had been diagnosed with diffuse large B-cell lymphoma of the paranasal sinuses and was in remission after chemotherapy. Because metastasis of the lymphoma was suspected, he underwent PPV, and intraocular samples were collected as in Case 1.Results: Atypical lymphoid cells were detected from the infusion fluid in both cases. The ratio of interleukin (IL)-10 to IL-6 was greater than 1.0 in both cases. These results allowed us to make a diagnosis of intraocular lymphoma: primary intraocular lymphoma in Case 1 and metastatic intraocular lymphoma in Case 2.Conclusion: Vitreous and infusion fluid collected during PPV can be used for diagnosing an intraocular lymphoma.Keywords: intraocular lymphoma, cytological analysis, vitreous, pars plana vitrectomy, infusion fluid
format	article
author	Matsuoka M Yoshida H Kinoshita Y Nishimura T
author_facet	Matsuoka M Yoshida H Kinoshita Y Nishimura T
author_sort	Matsuoka M
title	Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
title_short	Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
title_full	Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
title_fullStr	Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
title_full_unstemmed	Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
title_sort	two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/9a4bf403b03544c3928fb7a3e5506db4
work_keys_str_mv	AT matsuokam twocasesofintraocularlymphomadiagnosedbyanalysesofvitreousandinfusionfluid AT yoshidah twocasesofintraocularlymphomadiagnosedbyanalysesofvitreousandinfusionfluid AT kinoshitay twocasesofintraocularlymphomadiagnosedbyanalysesofvitreousandinfusionfluid AT nishimurat twocasesofintraocularlymphomadiagnosedbyanalysesofvitreousandinfusionfluid
_version_	1718401025864368128

Two cases of intraocular lymphoma diagnosed by analyses of vitreous and infusion fluid

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