Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study

Background: Carnitine supplementation improves various dialysis-related symptoms including erythropoietin-resistant anemia in patients who are undergoing hemodialysis. However, the utility of carnitine supplementation in patients who are undergoing peritoneal dialysis (PD) is not fully understood.Me...

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Autores principales:	Shohei Kaneko, Katsunori Yanai, Taisuke Kitano, Haruhisa Miyazawa, Keiji Hirai, Susumu Ookawara, Yoshiyuki Morishita
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carnitine deficiency carnitine supplementation peritoneal dialysis erythropoietin resistance index erythropoietin-resistant anemia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9a5182f60eea4f26a05300a47e56f79b
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spelling	oai:doaj.org-article:9a5182f60eea4f26a05300a47e56f79b2021-11-05T09:34:58ZChange in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study2296-858X10.3389/fmed.2021.767945https://doaj.org/article/9a5182f60eea4f26a05300a47e56f79b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.767945/fullhttps://doaj.org/toc/2296-858XBackground: Carnitine supplementation improves various dialysis-related symptoms including erythropoietin-resistant anemia in patients who are undergoing hemodialysis. However, the utility of carnitine supplementation in patients who are undergoing peritoneal dialysis (PD) is not fully understood.Methods: Thirteen patients undergoing PD [mean age: 54.2 ± 14.8 years, males: 9/13 (69%)] administered oral carnitine supplementation (mean dose: 9.1 ± 3.3 mg/kg/day) for 4–6 months were retrospectively investigated. Changes in serum carnitine levels and other clinical variables including the erythropoietin resistance index (ERI) were analyzed after carnitine supplementation.Results: Carnitine supplementation increased serum total carnitine (48.5 ± 10.2 vs. 130.1 ± 37.2 μmol/L, P < 0.01), free carnitine (31.1 ± 8.3 vs. 83.1 ± 24.6 μmol/L, P < 0.01), and acyl carnitine (17.4 ± 2.8 vs. 46.9 ± 13.8, P < 0.01) levels. The acyl carnitine/free carnitine ratio was not affected (0.6 ± 0.1 vs. 0.6 ± 0.1, P = 0.75). Although the mean ERI was not affected by carnitine supplementation [13.7 ± 4.7 vs. 11.6 ± 3.4 IU/kg/(g/dL)/week, P = 0.28], the ERI change rate was significantly decreased (1.00 ± 0.00 vs. 0.87 ± 0.11, P < 0.01).Conclusion: Carnitine supplementation may improve erythropoietin resistance in patients who are undergoing PD.Shohei KanekoKatsunori YanaiTaisuke KitanoHaruhisa MiyazawaKeiji HiraiSusumu OokawaraYoshiyuki MorishitaFrontiers Media S.A.articlecarnitine deficiencycarnitine supplementationperitoneal dialysiserythropoietin resistance indexerythropoietin-resistant anemiaMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carnitine deficiency carnitine supplementation peritoneal dialysis erythropoietin resistance index erythropoietin-resistant anemia Medicine (General) R5-920
spellingShingle	carnitine deficiency carnitine supplementation peritoneal dialysis erythropoietin resistance index erythropoietin-resistant anemia Medicine (General) R5-920 Shohei Kaneko Katsunori Yanai Taisuke Kitano Haruhisa Miyazawa Keiji Hirai Susumu Ookawara Yoshiyuki Morishita Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study
description	Background: Carnitine supplementation improves various dialysis-related symptoms including erythropoietin-resistant anemia in patients who are undergoing hemodialysis. However, the utility of carnitine supplementation in patients who are undergoing peritoneal dialysis (PD) is not fully understood.Methods: Thirteen patients undergoing PD [mean age: 54.2 ± 14.8 years, males: 9/13 (69%)] administered oral carnitine supplementation (mean dose: 9.1 ± 3.3 mg/kg/day) for 4–6 months were retrospectively investigated. Changes in serum carnitine levels and other clinical variables including the erythropoietin resistance index (ERI) were analyzed after carnitine supplementation.Results: Carnitine supplementation increased serum total carnitine (48.5 ± 10.2 vs. 130.1 ± 37.2 μmol/L, P < 0.01), free carnitine (31.1 ± 8.3 vs. 83.1 ± 24.6 μmol/L, P < 0.01), and acyl carnitine (17.4 ± 2.8 vs. 46.9 ± 13.8, P < 0.01) levels. The acyl carnitine/free carnitine ratio was not affected (0.6 ± 0.1 vs. 0.6 ± 0.1, P = 0.75). Although the mean ERI was not affected by carnitine supplementation [13.7 ± 4.7 vs. 11.6 ± 3.4 IU/kg/(g/dL)/week, P = 0.28], the ERI change rate was significantly decreased (1.00 ± 0.00 vs. 0.87 ± 0.11, P < 0.01).Conclusion: Carnitine supplementation may improve erythropoietin resistance in patients who are undergoing PD.
format	article
author	Shohei Kaneko Katsunori Yanai Taisuke Kitano Haruhisa Miyazawa Keiji Hirai Susumu Ookawara Yoshiyuki Morishita
author_facet	Shohei Kaneko Katsunori Yanai Taisuke Kitano Haruhisa Miyazawa Keiji Hirai Susumu Ookawara Yoshiyuki Morishita
author_sort	Shohei Kaneko
title	Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study
title_short	Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study
title_full	Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study
title_fullStr	Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study
title_full_unstemmed	Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study
title_sort	change in anemia by carnitine supplementation in patients undergoing peritoneal dialysis: a retrospective observational study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9a5182f60eea4f26a05300a47e56f79b
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Change in Anemia by Carnitine Supplementation in Patients Undergoing Peritoneal Dialysis: A Retrospective Observational Study

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