CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice

Abstract Successful pregnancy inevitably depends on the implantation of a competent embryo into a receptive endometrium. Although many substances have been suggested to improve the rate of embryo implantation targeting enhancement of endometrial receptivity, currently there rarely are effective evid...

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Autores principales:	Hwa Seon Koo, Min-Ji Yoon, Seon-Hwa Hong, Jungho Ahn, Hwijae Cha, Danbi Lee, Ji-Eun Ko, Hwang Kwon, Dong Hee Choi, Kyung-Ah Lee, Jung-Jae Ko, Youn-Jung Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a5353de445e4f008c475f9dd5aca67c
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spelling	oai:doaj.org-article:9a5353de445e4f008c475f9dd5aca67c2021-12-02T18:17:54ZCXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice10.1038/s41598-021-86956-y2045-2322https://doaj.org/article/9a5353de445e4f008c475f9dd5aca67c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86956-yhttps://doaj.org/toc/2045-2322Abstract Successful pregnancy inevitably depends on the implantation of a competent embryo into a receptive endometrium. Although many substances have been suggested to improve the rate of embryo implantation targeting enhancement of endometrial receptivity, currently there rarely are effective evidence-based treatments to prevent or cure this condition. Here we strongly suggest minimally-invasive intra-uterine administration of embryo-secreted chemokine CXCL12 as an effective therapeutic intervention. Chemokine CXCL12 derived from pre- and peri-implanting embryos significantly enhances the rates of embryo attachment and promoted endothelial vessel formation and sprouting in vitro. Consistently, intra-uterine CXCL12 administration in C57BL/6 mice improved endometrial receptivity showing increased integrin β3 and its ligand osteopontin, and induced endometrial angiogenesis displaying increased numbers of vessel formation near the lining of endometrial epithelial layer with higher CD31 and CD34 expression. Furthermore, intra-uterine CXCL12 application dramatically promoted the rates of embryo implantation with no morphologically retarded embryos. Thus, our present study provides a novel evidence that improved uterine endometrial receptivity and enhanced angiogenesis induced by embryo-derived chemokine CXCL12 may aid to develop a minimally-invasive therapeutic strategy for clinical treatment or supplement for the patients with repeated implantation failure with less risk.Hwa Seon KooMin-Ji YoonSeon-Hwa HongJungho AhnHwijae ChaDanbi LeeJi-Eun KoHwang KwonDong Hee ChoiKyung-Ah LeeJung-Jae KoYoun-Jung KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hwa Seon Koo Min-Ji Yoon Seon-Hwa Hong Jungho Ahn Hwijae Cha Danbi Lee Ji-Eun Ko Hwang Kwon Dong Hee Choi Kyung-Ah Lee Jung-Jae Ko Youn-Jung Kang CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
description	Abstract Successful pregnancy inevitably depends on the implantation of a competent embryo into a receptive endometrium. Although many substances have been suggested to improve the rate of embryo implantation targeting enhancement of endometrial receptivity, currently there rarely are effective evidence-based treatments to prevent or cure this condition. Here we strongly suggest minimally-invasive intra-uterine administration of embryo-secreted chemokine CXCL12 as an effective therapeutic intervention. Chemokine CXCL12 derived from pre- and peri-implanting embryos significantly enhances the rates of embryo attachment and promoted endothelial vessel formation and sprouting in vitro. Consistently, intra-uterine CXCL12 administration in C57BL/6 mice improved endometrial receptivity showing increased integrin β3 and its ligand osteopontin, and induced endometrial angiogenesis displaying increased numbers of vessel formation near the lining of endometrial epithelial layer with higher CD31 and CD34 expression. Furthermore, intra-uterine CXCL12 application dramatically promoted the rates of embryo implantation with no morphologically retarded embryos. Thus, our present study provides a novel evidence that improved uterine endometrial receptivity and enhanced angiogenesis induced by embryo-derived chemokine CXCL12 may aid to develop a minimally-invasive therapeutic strategy for clinical treatment or supplement for the patients with repeated implantation failure with less risk.
format	article
author	Hwa Seon Koo Min-Ji Yoon Seon-Hwa Hong Jungho Ahn Hwijae Cha Danbi Lee Ji-Eun Ko Hwang Kwon Dong Hee Choi Kyung-Ah Lee Jung-Jae Ko Youn-Jung Kang
author_facet	Hwa Seon Koo Min-Ji Yoon Seon-Hwa Hong Jungho Ahn Hwijae Cha Danbi Lee Ji-Eun Ko Hwang Kwon Dong Hee Choi Kyung-Ah Lee Jung-Jae Ko Youn-Jung Kang
author_sort	Hwa Seon Koo
title	CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
title_short	CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
title_full	CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
title_fullStr	CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
title_full_unstemmed	CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
title_sort	cxcl12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9a5353de445e4f008c475f9dd5aca67c
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CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice

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