Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

Burak Çelik,1 Ali Asram Sağıroğlu,1 Samet Özdemir2 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Bezmialem Vakif University, 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey Abstract: Coenzyme Q10 (CoQ10) is a...

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Autores principales:	Çelik B, Sağıroğlu AA, Özdemir S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	coenzyme q10 D-panthenyl triacetate liposome response surface methodology stability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9a55f16c00bc464297b80229e57662aa
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spelling	oai:doaj.org-article:9a55f16c00bc464297b80229e57662aa2021-12-02T00:37:18ZDesign, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes1178-2013https://doaj.org/article/9a55f16c00bc464297b80229e57662aa2017-07-01T00:00:00Zhttps://www.dovepress.com/design-optimization-and-characterization-of-coenzyme-q10--and-d-panthe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Burak Çelik,1 Ali Asram Sağıroğlu,1 Samet Özdemir2 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Bezmialem Vakif University, 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey Abstract: Coenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications. Keywords: coenzyme Q10, D-panthenyl triacetate, liposomes, response surface methodology, stabilityÇelik BSağıroğlu AAÖzdemir SDove Medical Pressarticlecoenzyme q10D-panthenyl triacetateliposomeresponse surface methodologystabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4869-4878 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	coenzyme q10 D-panthenyl triacetate liposome response surface methodology stability Medicine (General) R5-920
spellingShingle	coenzyme q10 D-panthenyl triacetate liposome response surface methodology stability Medicine (General) R5-920 Çelik B Sağıroğlu AA Özdemir S Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes
description	Burak Çelik,1 Ali Asram Sağıroğlu,1 Samet Özdemir2 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Bezmialem Vakif University, 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey Abstract: Coenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications. Keywords: coenzyme Q10, D-panthenyl triacetate, liposomes, response surface methodology, stability
format	article
author	Çelik B Sağıroğlu AA Özdemir S
author_facet	Çelik B Sağıroğlu AA Özdemir S
author_sort	Çelik B
title	Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes
title_short	Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes
title_full	Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes
title_fullStr	Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes
title_full_unstemmed	Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes
title_sort	design, optimization and characterization of coenzyme q10- and d-panthenyl triacetate-loaded liposomes
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9a55f16c00bc464297b80229e57662aa
work_keys_str_mv	AT celikb designoptimizationandcharacterizationofcoenzymeq10anddpanthenyltriacetateloadedliposomes AT sagırogluaa designoptimizationandcharacterizationofcoenzymeq10anddpanthenyltriacetateloadedliposomes AT ozdemirs designoptimizationandcharacterizationofcoenzymeq10anddpanthenyltriacetateloadedliposomes
_version_	1718403634041978880

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

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