Dark urine as the initial manifestation of COVID-19: a case report

Abstract Background Rhabdomyolysis is defined as a syndrome consisting of muscle necrosis and the release of intracellular muscle components into the bloodstream. Although rhabdomyolysis has been previously reported as an initial presentation or late complication of COVID-19, the data on it is still...

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Autores principales:	Goar Egoryan, Sana Chaudry, Kritika Yadav, Tianyu Dong, Emre Ozcekirdek, Ece Ozen, Guillermo Rodriguez-Nava
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Rhabdomyolysis Creatine kinase COVID-19 Coronavirus SARS-CoV-2 Medicine R
Acceso en línea:	https://doaj.org/article/9a5639ab35c748ca933910563d8a4d35
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spelling	oai:doaj.org-article:9a5639ab35c748ca933910563d8a4d352021-12-05T12:23:50ZDark urine as the initial manifestation of COVID-19: a case report10.1186/s13256-021-03173-x1752-1947https://doaj.org/article/9a5639ab35c748ca933910563d8a4d352021-12-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03173-xhttps://doaj.org/toc/1752-1947Abstract Background Rhabdomyolysis is defined as a syndrome consisting of muscle necrosis and the release of intracellular muscle components into the bloodstream. Although rhabdomyolysis has been previously reported as an initial presentation or late complication of COVID-19, the data on it is still limited, and currently, there is no single case of COVID-19 in the literature that describes creatine kinase levels of more than 30,000 IU/L. Case presentation A 50-year-old African–American male presented to the hospital with decreased urine output, dark urine color, and constipation for the past couple of days. He was found to have acute kidney injury, liver injury, and creatinine kinase of 359,910 IU/L, for which aggressive intravenous fluid therapy was given. Infectious workup resulted in positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction. Two days after admission, the patient became symptomatic from a coronavirus disease 2019: he developed fever and hypoxia, and was placed on supplemental oxygen and started on a 10-day course of dexamethasone. The patient responded well to the treatment and supportive care for coronavirus disease 2019 and was successfully discharged. Conclusion Clinicians should be cognizant of atypical coronavirus disease 2019 presentations. The spectrum of damage of coronavirus disease 2019 is still an evolving topic, and more research is required to reveal the exact mechanisms by which severe acute respiratory syndrome coronavirus 2 leads to rhabdomyolysis.Goar EgoryanSana ChaudryKritika YadavTianyu DongEmre OzcekirdekEce OzenGuillermo Rodriguez-NavaBMCarticleRhabdomyolysisCreatine kinaseCOVID-19CoronavirusSARS-CoV-2MedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rhabdomyolysis Creatine kinase COVID-19 Coronavirus SARS-CoV-2 Medicine R
spellingShingle	Rhabdomyolysis Creatine kinase COVID-19 Coronavirus SARS-CoV-2 Medicine R Goar Egoryan Sana Chaudry Kritika Yadav Tianyu Dong Emre Ozcekirdek Ece Ozen Guillermo Rodriguez-Nava Dark urine as the initial manifestation of COVID-19: a case report
description	Abstract Background Rhabdomyolysis is defined as a syndrome consisting of muscle necrosis and the release of intracellular muscle components into the bloodstream. Although rhabdomyolysis has been previously reported as an initial presentation or late complication of COVID-19, the data on it is still limited, and currently, there is no single case of COVID-19 in the literature that describes creatine kinase levels of more than 30,000 IU/L. Case presentation A 50-year-old African–American male presented to the hospital with decreased urine output, dark urine color, and constipation for the past couple of days. He was found to have acute kidney injury, liver injury, and creatinine kinase of 359,910 IU/L, for which aggressive intravenous fluid therapy was given. Infectious workup resulted in positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction. Two days after admission, the patient became symptomatic from a coronavirus disease 2019: he developed fever and hypoxia, and was placed on supplemental oxygen and started on a 10-day course of dexamethasone. The patient responded well to the treatment and supportive care for coronavirus disease 2019 and was successfully discharged. Conclusion Clinicians should be cognizant of atypical coronavirus disease 2019 presentations. The spectrum of damage of coronavirus disease 2019 is still an evolving topic, and more research is required to reveal the exact mechanisms by which severe acute respiratory syndrome coronavirus 2 leads to rhabdomyolysis.
format	article
author	Goar Egoryan Sana Chaudry Kritika Yadav Tianyu Dong Emre Ozcekirdek Ece Ozen Guillermo Rodriguez-Nava
author_facet	Goar Egoryan Sana Chaudry Kritika Yadav Tianyu Dong Emre Ozcekirdek Ece Ozen Guillermo Rodriguez-Nava
author_sort	Goar Egoryan
title	Dark urine as the initial manifestation of COVID-19: a case report
title_short	Dark urine as the initial manifestation of COVID-19: a case report
title_full	Dark urine as the initial manifestation of COVID-19: a case report
title_fullStr	Dark urine as the initial manifestation of COVID-19: a case report
title_full_unstemmed	Dark urine as the initial manifestation of COVID-19: a case report
title_sort	dark urine as the initial manifestation of covid-19: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9a5639ab35c748ca933910563d8a4d35
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Dark urine as the initial manifestation of COVID-19: a case report

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