THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN

The present work evaluates ibuprofen wettability recrystallized by the evaporation solvent method in ethanol, methanol and hexane. Previously, an operational qualification of the gonyometer is realized by means of the determination of the PTFE-water system wettability, finding good precision represe...

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Autores principales:	Jorge A. GIL Q., Leidy J. VARGAS M., Oscar A. FLOREZ A., Gloria E. TOBÓN Z.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	wettability ibuprofen recristalization crystal habit particle size contact angle. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/9a5866651d564a9d98806871e939e424
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spelling	oai:doaj.org-article:9a5866651d564a9d98806871e939e4242021-11-19T04:16:35ZTHE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN0121-40042145-2660https://doaj.org/article/9a5866651d564a9d98806871e939e4242009-05-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/1425https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The present work evaluates ibuprofen wettability recrystallized by the evaporation solvent method in ethanol, methanol and hexane. Previously, an operational qualification of the gonyometer is realized by means of the determination of the PTFE-water system wettability, finding good precision represented by a variation coefficient of 2.49% (Total variability). It obtains crystalline prismatic habits for the ibuprofen recrystallized in ethanol and methanol, and needle-shaped on having used hexane as solvent; moreover, in the X-ray diffraction analysis to establish the internal structure the three products prove isomorphs. The contact angle is determinated for the three forms recrystallized in three ranges of particle size, finding that the minor value of contact angle or the best wettability is presented by ibuprofen recrystallized in ethanol, with an average size of 120 µm, giving information of the most adequate shape type and size particle in the formulation of the tablets of this substance. Jorge A. GIL Q.Leidy J. VARGAS M.Oscar A. FLOREZ A.Gloria E. TOBÓN Z.Universidad de Antioquiaarticlewettabilityibuprofenrecristalizationcrystal habitparticle sizecontact angle.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	wettability ibuprofen recristalization crystal habit particle size contact angle. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	wettability ibuprofen recristalization crystal habit particle size contact angle. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Jorge A. GIL Q. Leidy J. VARGAS M. Oscar A. FLOREZ A. Gloria E. TOBÓN Z. THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
description	The present work evaluates ibuprofen wettability recrystallized by the evaporation solvent method in ethanol, methanol and hexane. Previously, an operational qualification of the gonyometer is realized by means of the determination of the PTFE-water system wettability, finding good precision represented by a variation coefficient of 2.49% (Total variability). It obtains crystalline prismatic habits for the ibuprofen recrystallized in ethanol and methanol, and needle-shaped on having used hexane as solvent; moreover, in the X-ray diffraction analysis to establish the internal structure the three products prove isomorphs. The contact angle is determinated for the three forms recrystallized in three ranges of particle size, finding that the minor value of contact angle or the best wettability is presented by ibuprofen recrystallized in ethanol, with an average size of 120 µm, giving information of the most adequate shape type and size particle in the formulation of the tablets of this substance.
format	article
author	Jorge A. GIL Q. Leidy J. VARGAS M. Oscar A. FLOREZ A. Gloria E. TOBÓN Z.
author_facet	Jorge A. GIL Q. Leidy J. VARGAS M. Oscar A. FLOREZ A. Gloria E. TOBÓN Z.
author_sort	Jorge A. GIL Q.
title	THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
title_short	THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
title_full	THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
title_fullStr	THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
title_full_unstemmed	THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
title_sort	effect of the solvent recrystallization and particle size on wettability of ibuprofen
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/9a5866651d564a9d98806871e939e424
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THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN

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