Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

Infertility is a worldwide concern that can be treated with in vitro fertilization (IVF). Improvements in IVF and infertility treatment depend largely on better understanding of the molecular mechanisms for human preimplantation development. Several large-scale studies have been conducted to identif...

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Autores principales:	Elo Madissoon, Virpi Töhönen, Liselotte Vesterlund, Shintaro Katayama, Per Unneberg, Jose Inzunza, Outi Hovatta, Juha Kere
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a6193b6f1564e468da9439ed1e5a360
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spelling	oai:doaj.org-article:9a6193b6f1564e468da9439ed1e5a3602021-11-25T06:06:06ZDifferences in gene expression between mouse and human for dynamically regulated genes in early embryo.1932-620310.1371/journal.pone.0102949https://doaj.org/article/9a6193b6f1564e468da9439ed1e5a3602014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25089626/?tool=EBIhttps://doaj.org/toc/1932-6203Infertility is a worldwide concern that can be treated with in vitro fertilization (IVF). Improvements in IVF and infertility treatment depend largely on better understanding of the molecular mechanisms for human preimplantation development. Several large-scale studies have been conducted to identify gene expression patterns for the first five days of human development, and many functional studies utilize mouse as a model system. We have identified genes of possible importance for this time period by analyzing human microarray data and available data from online databases. We selected 70 candidate genes for human preimplantation development and investigated their expression in the early mouse development from oocyte to the 8-cell stage. Maternally loaded genes expectedly decreased in expression during development both in human and mouse. We discovered that 25 significantly upregulated genes after fertilization in human included 13 genes whose orthologs in mouse behaved differently and mimicked the expression profile of maternally expressed genes. Our findings highlight many significant differences in gene expression patterns during mouse and human preimplantation development. We also describe four cancer-testis antigen families that are also highly expressed in human embryos: PRAME, SSX, GAGE and MAGEA.Elo MadissoonVirpi TöhönenLiselotte VesterlundShintaro KatayamaPer UnnebergJose InzunzaOuti HovattaJuha KerePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e102949 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elo Madissoon Virpi Töhönen Liselotte Vesterlund Shintaro Katayama Per Unneberg Jose Inzunza Outi Hovatta Juha Kere Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
description	Infertility is a worldwide concern that can be treated with in vitro fertilization (IVF). Improvements in IVF and infertility treatment depend largely on better understanding of the molecular mechanisms for human preimplantation development. Several large-scale studies have been conducted to identify gene expression patterns for the first five days of human development, and many functional studies utilize mouse as a model system. We have identified genes of possible importance for this time period by analyzing human microarray data and available data from online databases. We selected 70 candidate genes for human preimplantation development and investigated their expression in the early mouse development from oocyte to the 8-cell stage. Maternally loaded genes expectedly decreased in expression during development both in human and mouse. We discovered that 25 significantly upregulated genes after fertilization in human included 13 genes whose orthologs in mouse behaved differently and mimicked the expression profile of maternally expressed genes. Our findings highlight many significant differences in gene expression patterns during mouse and human preimplantation development. We also describe four cancer-testis antigen families that are also highly expressed in human embryos: PRAME, SSX, GAGE and MAGEA.
format	article
author	Elo Madissoon Virpi Töhönen Liselotte Vesterlund Shintaro Katayama Per Unneberg Jose Inzunza Outi Hovatta Juha Kere
author_facet	Elo Madissoon Virpi Töhönen Liselotte Vesterlund Shintaro Katayama Per Unneberg Jose Inzunza Outi Hovatta Juha Kere
author_sort	Elo Madissoon
title	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
title_short	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
title_full	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
title_fullStr	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
title_full_unstemmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
title_sort	differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/9a6193b6f1564e468da9439ed1e5a360
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Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

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