Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks

Abstract A novel pandemic influenza A(H1N1)pdm09 virus emerged in 2009 globally, and it continues to circulate in humans. The National Influenza Surveillance Network in Taiwan identified five A(H1N1)pdm09-predominant seasons, representing the 2009/2010, 2010/2011, 2012/2013, 2013/2014, and 2015/2016...

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Autores principales:	Yu-Chia Hsieh, Kuo-Chien Tsao, Ching-Tai Huang, Kuang-Yi Chang, Yhu-Chering Huang, Yu-Nong Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Laboratory-confirmed Influenza Pdm09 Virus Influenza-related Complications Chang Gung Memorial Hospital Acute Respiratory Distress Syndrome Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a64de191665437bbd0faadfd766f546
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spelling	oai:doaj.org-article:9a64de191665437bbd0faadfd766f5462021-12-02T11:40:24ZClinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks10.1038/s41598-018-34077-42045-2322https://doaj.org/article/9a64de191665437bbd0faadfd766f5462018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34077-4https://doaj.org/toc/2045-2322Abstract A novel pandemic influenza A(H1N1)pdm09 virus emerged in 2009 globally, and it continues to circulate in humans. The National Influenza Surveillance Network in Taiwan identified five A(H1N1)pdm09-predominant seasons, representing the 2009/2010, 2010/2011, 2012/2013, 2013/2014, and 2015/2016 outbreaks from 2009 to 2016. Independently, a retrospective cohort study (which enrolled 639 infected patients during the five seasons) was conducted at Chang Gung Memorial Hospital to explore the risk factors associated with influenza A(H1N1)pdm09-related complications. A phylogenetic analysis of hemagglutinin (HA) sequences showed that the circulating A(H1N1)pdm09 virus belonged to clades 1, 2, and 8 in 2009/2010; clades 3, 4, 5, and 7 in 2010/2011; clades 7 and 6C in 2012/2013; clades 6B in 2013/2014; and 6B/6B.1/6B.2 in 2015/2016. Compared to individuals infected in non-6B/6B.1/6B.2 seasons (2009/2010, 2010/2011, and 2012/2013), those infected in 6B/6B.1/6B.2 seasons (2013/2014 and 2015/2016) were at higher risk for influenza-related complications (adjusted odds ratio [aOR]: 1.6, 95% confidence interval [CI]: 1.0–2.8), pneumonia (aOR: 1.78, 95% CI: 1.04–3.04), mechanical ventilation (aOR: 2.6, 95% CI: 1.2–5.6), and acute respiratory distress syndrome (aOR: 5.5, 95% CI: 1.9–15.9). For the increased severity of infection during the influenza A(H1N1)pdm09 clade 6B/6B.1/6B.2 seasons, aspects related to the antigenic change of A(H1N1)pdm09 virus, immune response of the host, and environmental factors required further investigation.Yu-Chia HsiehKuo-Chien TsaoChing-Tai HuangKuang-Yi ChangYhu-Chering HuangYu-Nong GongNature PortfolioarticleLaboratory-confirmed InfluenzaPdm09 VirusInfluenza-related ComplicationsChang Gung Memorial HospitalAcute Respiratory Distress SyndromeMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Laboratory-confirmed Influenza Pdm09 Virus Influenza-related Complications Chang Gung Memorial Hospital Acute Respiratory Distress Syndrome Medicine R Science Q
spellingShingle	Laboratory-confirmed Influenza Pdm09 Virus Influenza-related Complications Chang Gung Memorial Hospital Acute Respiratory Distress Syndrome Medicine R Science Q Yu-Chia Hsieh Kuo-Chien Tsao Ching-Tai Huang Kuang-Yi Chang Yhu-Chering Huang Yu-Nong Gong Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
description	Abstract A novel pandemic influenza A(H1N1)pdm09 virus emerged in 2009 globally, and it continues to circulate in humans. The National Influenza Surveillance Network in Taiwan identified five A(H1N1)pdm09-predominant seasons, representing the 2009/2010, 2010/2011, 2012/2013, 2013/2014, and 2015/2016 outbreaks from 2009 to 2016. Independently, a retrospective cohort study (which enrolled 639 infected patients during the five seasons) was conducted at Chang Gung Memorial Hospital to explore the risk factors associated with influenza A(H1N1)pdm09-related complications. A phylogenetic analysis of hemagglutinin (HA) sequences showed that the circulating A(H1N1)pdm09 virus belonged to clades 1, 2, and 8 in 2009/2010; clades 3, 4, 5, and 7 in 2010/2011; clades 7 and 6C in 2012/2013; clades 6B in 2013/2014; and 6B/6B.1/6B.2 in 2015/2016. Compared to individuals infected in non-6B/6B.1/6B.2 seasons (2009/2010, 2010/2011, and 2012/2013), those infected in 6B/6B.1/6B.2 seasons (2013/2014 and 2015/2016) were at higher risk for influenza-related complications (adjusted odds ratio [aOR]: 1.6, 95% confidence interval [CI]: 1.0–2.8), pneumonia (aOR: 1.78, 95% CI: 1.04–3.04), mechanical ventilation (aOR: 2.6, 95% CI: 1.2–5.6), and acute respiratory distress syndrome (aOR: 5.5, 95% CI: 1.9–15.9). For the increased severity of infection during the influenza A(H1N1)pdm09 clade 6B/6B.1/6B.2 seasons, aspects related to the antigenic change of A(H1N1)pdm09 virus, immune response of the host, and environmental factors required further investigation.
format	article
author	Yu-Chia Hsieh Kuo-Chien Tsao Ching-Tai Huang Kuang-Yi Chang Yhu-Chering Huang Yu-Nong Gong
author_facet	Yu-Chia Hsieh Kuo-Chien Tsao Ching-Tai Huang Kuang-Yi Chang Yhu-Chering Huang Yu-Nong Gong
author_sort	Yu-Chia Hsieh
title	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
title_short	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
title_full	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
title_fullStr	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
title_full_unstemmed	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
title_sort	clinical characteristics of patients with laboratory-confirmed influenza a(h1n1)pdm09 during the 2013/2014 and 2015/2016 clade 6b/6b.1/6b.2-predominant outbreaks
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9a64de191665437bbd0faadfd766f546
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Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks

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