Heterogeneity Confounds Establishment of “a” Model Microbial Strain

ABSTRACT Aspergillus fumigatus is a ubiquitous environmental mold and the leading cause of diverse human diseases ranging from allergenic bronchopulmonary aspergillosis (ABPA) to invasive pulmonary aspergillosis (IPA). Experimental investigations of the biology and virulence of this opportunistic pa...

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Autor principal:	Nancy P. Keller
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9a69c7e7accc46f2a4afad08ea33d5d1
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spelling	oai:doaj.org-article:9a69c7e7accc46f2a4afad08ea33d5d12021-11-15T15:51:08ZHeterogeneity Confounds Establishment of “a” Model Microbial Strain10.1128/mBio.00135-172150-7511https://doaj.org/article/9a69c7e7accc46f2a4afad08ea33d5d12017-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00135-17https://doaj.org/toc/2150-7511ABSTRACT Aspergillus fumigatus is a ubiquitous environmental mold and the leading cause of diverse human diseases ranging from allergenic bronchopulmonary aspergillosis (ABPA) to invasive pulmonary aspergillosis (IPA). Experimental investigations of the biology and virulence of this opportunistic pathogen have historically used a few type strains; however, it is increasingly observed with this fungus that heterogeneity among isolates potentially confounds the use of these reference isolates. Illustrating this point, Kowalski et al. (mBio 7:e01515-16, 2016, https://doi.org/10.1128/mBio.01515-16 ) demonstrated that variation in 16 environmental and clinical isolates of A. fumigatus correlated virulence with fitness in low oxygen, whereas Fuller et al. (mBio 7:e01517-16, 2016, https://doi.org/10.1128/mBio.01517-16 ) showed wide variation in light responses at a physiological and protein functionality level in 15 A. fumigatus isolates. In both studies, two commonly used type strains, Af293 and CEA10, displayed significant differences in physiological responses to abiotic stimuli and virulence in a murine model of IPA.Nancy P. KellerAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 8, Iss 1 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Nancy P. Keller Heterogeneity Confounds Establishment of “a” Model Microbial Strain
description	ABSTRACT Aspergillus fumigatus is a ubiquitous environmental mold and the leading cause of diverse human diseases ranging from allergenic bronchopulmonary aspergillosis (ABPA) to invasive pulmonary aspergillosis (IPA). Experimental investigations of the biology and virulence of this opportunistic pathogen have historically used a few type strains; however, it is increasingly observed with this fungus that heterogeneity among isolates potentially confounds the use of these reference isolates. Illustrating this point, Kowalski et al. (mBio 7:e01515-16, 2016, https://doi.org/10.1128/mBio.01515-16 ) demonstrated that variation in 16 environmental and clinical isolates of A. fumigatus correlated virulence with fitness in low oxygen, whereas Fuller et al. (mBio 7:e01517-16, 2016, https://doi.org/10.1128/mBio.01517-16 ) showed wide variation in light responses at a physiological and protein functionality level in 15 A. fumigatus isolates. In both studies, two commonly used type strains, Af293 and CEA10, displayed significant differences in physiological responses to abiotic stimuli and virulence in a murine model of IPA.
format	article
author	Nancy P. Keller
author_facet	Nancy P. Keller
author_sort	Nancy P. Keller
title	Heterogeneity Confounds Establishment of “a” Model Microbial Strain
title_short	Heterogeneity Confounds Establishment of “a” Model Microbial Strain
title_full	Heterogeneity Confounds Establishment of “a” Model Microbial Strain
title_fullStr	Heterogeneity Confounds Establishment of “a” Model Microbial Strain
title_full_unstemmed	Heterogeneity Confounds Establishment of “a” Model Microbial Strain
title_sort	heterogeneity confounds establishment of “a” model microbial strain
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/9a69c7e7accc46f2a4afad08ea33d5d1
work_keys_str_mv	AT nancypkeller heterogeneityconfoundsestablishmentofamodelmicrobialstrain
_version_	1718427415285334016

Heterogeneity Confounds Establishment of “a” Model Microbial Strain

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