Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.

The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations...

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Autores principales:	Kai Yuan, Chenwang Jin, Ping Cheng, Xuejuan Yang, Tao Dong, Yanzhi Bi, Lihong Xing, Karen M von Deneen, Dahua Yu, Junyu Liu, Jun Liang, Tingting Cheng, Wei Qin, Jie Tian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a69eb10310143c48770e46ccb6a5d2e
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spelling	oai:doaj.org-article:9a69eb10310143c48770e46ccb6a5d2e2021-11-18T08:48:31ZAmplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.1932-620310.1371/journal.pone.0078708https://doaj.org/article/9a69eb10310143c48770e46ccb6a5d2e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223843/?tool=EBIhttps://doaj.org/toc/1932-6203The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD) during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control ability. In the present study, we employed the amplitude of low frequency fluctuation (ALFF) method to explore the local features of spontaneous brain activity in adolescents with OGA and healthy controls during resting-state. Eighteen adolescents with OGA and 18 age-, education- and gender-matched healthy volunteers participated in this study. Compared with healthy controls, adolescents with OGA showed a significant increase in ALFF values in the left medial orbitofrontal cortex (OFC), the left precuneus, the left supplementary motor area (SMA), the right parahippocampal gyrus (PHG) and the bilateral middle cingulate cortex (MCC). The abnormalities of these regions were also detected in previous addiction studies. More importantly, we found that ALFF values of the left medial OFC and left precuneus were positively correlated with the duration of OGA in adolescents with OGA. The ALFF values of the left medial OFC were also correlated with the color-word Stroop test performance. Our results suggested that the abnormal spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of OGA.Kai YuanChenwang JinPing ChengXuejuan YangTao DongYanzhi BiLihong XingKaren M von DeneenDahua YuJunyu LiuJun LiangTingting ChengWei QinJie TianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78708 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Yuan Chenwang Jin Ping Cheng Xuejuan Yang Tao Dong Yanzhi Bi Lihong Xing Karen M von Deneen Dahua Yu Junyu Liu Jun Liang Tingting Cheng Wei Qin Jie Tian Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
description	The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD) during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control ability. In the present study, we employed the amplitude of low frequency fluctuation (ALFF) method to explore the local features of spontaneous brain activity in adolescents with OGA and healthy controls during resting-state. Eighteen adolescents with OGA and 18 age-, education- and gender-matched healthy volunteers participated in this study. Compared with healthy controls, adolescents with OGA showed a significant increase in ALFF values in the left medial orbitofrontal cortex (OFC), the left precuneus, the left supplementary motor area (SMA), the right parahippocampal gyrus (PHG) and the bilateral middle cingulate cortex (MCC). The abnormalities of these regions were also detected in previous addiction studies. More importantly, we found that ALFF values of the left medial OFC and left precuneus were positively correlated with the duration of OGA in adolescents with OGA. The ALFF values of the left medial OFC were also correlated with the color-word Stroop test performance. Our results suggested that the abnormal spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of OGA.
format	article
author	Kai Yuan Chenwang Jin Ping Cheng Xuejuan Yang Tao Dong Yanzhi Bi Lihong Xing Karen M von Deneen Dahua Yu Junyu Liu Jun Liang Tingting Cheng Wei Qin Jie Tian
author_facet	Kai Yuan Chenwang Jin Ping Cheng Xuejuan Yang Tao Dong Yanzhi Bi Lihong Xing Karen M von Deneen Dahua Yu Junyu Liu Jun Liang Tingting Cheng Wei Qin Jie Tian
author_sort	Kai Yuan
title	Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
title_short	Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
title_full	Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
title_fullStr	Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
title_full_unstemmed	Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
title_sort	amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9a69eb10310143c48770e46ccb6a5d2e
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Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.

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