Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota

Microbiota acquired during labor and through the first days of life contributes to the newborn’s immune maturation and development. Mother provides probiotics and prebiotics factors through colostrum and maternal milk to shape the first neonatal microbiota. Previous works have reported that immunogl...

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Autores principales:	Erick Sánchez-Salguero, Karina Corona-Cervantes, Hector Armando Guzmán-Aquino, María Fernanda de la Borbolla-Cruz, Víctor Contreras-Vargas, Alberto Piña-Escobedo, Jaime García-Mena, Leopoldo Santos-Argumedo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	IgA2 IgA1 microbiota maternal transfer IgA-seq colostrum Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9a6a7ae038fc47e7a2eeb808891961bb
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spelling	oai:doaj.org-article:9a6a7ae038fc47e7a2eeb808891961bb2021-11-04T09:25:57ZMaternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota1664-322410.3389/fimmu.2021.712130https://doaj.org/article/9a6a7ae038fc47e7a2eeb808891961bb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.712130/fullhttps://doaj.org/toc/1664-3224Microbiota acquired during labor and through the first days of life contributes to the newborn’s immune maturation and development. Mother provides probiotics and prebiotics factors through colostrum and maternal milk to shape the first neonatal microbiota. Previous works have reported that immunoglobulin A (IgA) secreted in colostrum is coating a fraction of maternal microbiota. Thus, to better characterize this IgA-microbiota association, we used flow cytometry coupled with 16S rRNA gene sequencing (IgA-Seq) in human colostrum and neonatal feces. We identified IgA bound bacteria (IgA+) and characterized their diversity and composition shared in colostrum fractions and neonatal fecal bacteria. We found that IgA2 is mainly associated with Bifidobacterium, Pseudomonas, Lactobacillus, and Paracoccus, among other genera shared in colostrum and neonatal fecal samples. We found that metabolic pathways related to epithelial adhesion and carbohydrate consumption are enriched within the IgA2+ fecal microbiota. The association of IgA2 with specific bacteria could be explained because these antibodies recognize common antigens expressed on the surface of these bacterial genera. Our data suggest a preferential targeting of commensal bacteria by IgA2, revealing a possible function of maternal IgA2 in the shaping of the fecal microbial composition in the neonate during the first days of life.Erick Sánchez-SalgueroKarina Corona-CervantesHector Armando Guzmán-AquinoMaría Fernanda de la Borbolla-CruzVíctor Contreras-VargasAlberto Piña-EscobedoJaime García-MenaLeopoldo Santos-ArgumedoFrontiers Media S.A.articleIgA2IgA1microbiotamaternal transferIgA-seqcolostrumImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IgA2 IgA1 microbiota maternal transfer IgA-seq colostrum Immunologic diseases. Allergy RC581-607
spellingShingle	IgA2 IgA1 microbiota maternal transfer IgA-seq colostrum Immunologic diseases. Allergy RC581-607 Erick Sánchez-Salguero Karina Corona-Cervantes Hector Armando Guzmán-Aquino María Fernanda de la Borbolla-Cruz Víctor Contreras-Vargas Alberto Piña-Escobedo Jaime García-Mena Leopoldo Santos-Argumedo Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota
description	Microbiota acquired during labor and through the first days of life contributes to the newborn’s immune maturation and development. Mother provides probiotics and prebiotics factors through colostrum and maternal milk to shape the first neonatal microbiota. Previous works have reported that immunoglobulin A (IgA) secreted in colostrum is coating a fraction of maternal microbiota. Thus, to better characterize this IgA-microbiota association, we used flow cytometry coupled with 16S rRNA gene sequencing (IgA-Seq) in human colostrum and neonatal feces. We identified IgA bound bacteria (IgA+) and characterized their diversity and composition shared in colostrum fractions and neonatal fecal bacteria. We found that IgA2 is mainly associated with Bifidobacterium, Pseudomonas, Lactobacillus, and Paracoccus, among other genera shared in colostrum and neonatal fecal samples. We found that metabolic pathways related to epithelial adhesion and carbohydrate consumption are enriched within the IgA2+ fecal microbiota. The association of IgA2 with specific bacteria could be explained because these antibodies recognize common antigens expressed on the surface of these bacterial genera. Our data suggest a preferential targeting of commensal bacteria by IgA2, revealing a possible function of maternal IgA2 in the shaping of the fecal microbial composition in the neonate during the first days of life.
format	article
author	Erick Sánchez-Salguero Karina Corona-Cervantes Hector Armando Guzmán-Aquino María Fernanda de la Borbolla-Cruz Víctor Contreras-Vargas Alberto Piña-Escobedo Jaime García-Mena Leopoldo Santos-Argumedo
author_facet	Erick Sánchez-Salguero Karina Corona-Cervantes Hector Armando Guzmán-Aquino María Fernanda de la Borbolla-Cruz Víctor Contreras-Vargas Alberto Piña-Escobedo Jaime García-Mena Leopoldo Santos-Argumedo
author_sort	Erick Sánchez-Salguero
title	Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota
title_short	Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota
title_full	Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota
title_fullStr	Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota
title_full_unstemmed	Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota
title_sort	maternal iga2 recognizes similar fractions of colostrum and fecal neonatal microbiota
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9a6a7ae038fc47e7a2eeb808891961bb
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Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota

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