miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway

Summary: miR-1307 is highly expressed in liver cancer and inhibits methyltransferase protein8. Thereby, miR-1307 inhibits the expression of KDM3A and KDM3B and increases the methylation modification of histone H3 lysine 9, which enhances the expression of endoplasmic-reticulum-related gene CALR. Of...

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Autores principales:	Sijie Xie, Xiaoxue Jiang, Rushi Qin, Shuting Song, Yanan Lu, Liyan Wang, Yingjie Chen, Dongdong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Molecular biology Cell biology Cancer Science Q
Acceso en línea:	https://doaj.org/article/9a6b876f028443e084d27fbf4aa19d78
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spelling	oai:doaj.org-article:9a6b876f028443e084d27fbf4aa19d782021-11-20T05:09:08ZmiR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway2589-004210.1016/j.isci.2021.103271https://doaj.org/article/9a6b876f028443e084d27fbf4aa19d782021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012402https://doaj.org/toc/2589-0042Summary: miR-1307 is highly expressed in liver cancer and inhibits methyltransferase protein8. Thereby, miR-1307 inhibits the expression of KDM3A and KDM3B and increases the methylation modification of histone H3 lysine 9, which enhances the expression of endoplasmic-reticulum-related gene CALR. Of note, miR-1307 weakens the binding ability of OSTC to CDK2, CDK4, CyclinD1, and cyclinE and enhances the binding ability of CALR to CDK2, CDK4, CyclinD1, and cyclinE, decreasing of p21WAF1/CIP1, GADD45, pRB, and p18, and decreasing of ppRB. Furthermore, miR-1307 increases the activity of H-Ras, PKM2, and PLK1. Strikingly, miR-1307 reduces the binding ability of OSTC to ATG4 and enhances the binding ability of CALR to ATG4. Therefore, miR-1307 reduces the occurrence of autophagy based on ATG4-LC3-ATG3-ATG7-ATG5-ATG16L1-ATG12-ATG9- Beclin1. In particular, miR-1307 enhances the expression of PAK2, PLK1, PRKAR2A, MYBL1, and Trim44 and inhibits the expression of Sash1 and Smad5 via autophagy. Our observations suggest that miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway.Sijie XieXiaoxue JiangRushi QinShuting SongYanan LuLiyan WangYingjie ChenDongdong LuElsevierarticleMolecular biologyCell biologyCancerScienceQENiScience, Vol 24, Iss 11, Pp 103271- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Molecular biology Cell biology Cancer Science Q
spellingShingle	Molecular biology Cell biology Cancer Science Q Sijie Xie Xiaoxue Jiang Rushi Qin Shuting Song Yanan Lu Liyan Wang Yingjie Chen Dongdong Lu miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
description	Summary: miR-1307 is highly expressed in liver cancer and inhibits methyltransferase protein8. Thereby, miR-1307 inhibits the expression of KDM3A and KDM3B and increases the methylation modification of histone H3 lysine 9, which enhances the expression of endoplasmic-reticulum-related gene CALR. Of note, miR-1307 weakens the binding ability of OSTC to CDK2, CDK4, CyclinD1, and cyclinE and enhances the binding ability of CALR to CDK2, CDK4, CyclinD1, and cyclinE, decreasing of p21WAF1/CIP1, GADD45, pRB, and p18, and decreasing of ppRB. Furthermore, miR-1307 increases the activity of H-Ras, PKM2, and PLK1. Strikingly, miR-1307 reduces the binding ability of OSTC to ATG4 and enhances the binding ability of CALR to ATG4. Therefore, miR-1307 reduces the occurrence of autophagy based on ATG4-LC3-ATG3-ATG7-ATG5-ATG16L1-ATG12-ATG9- Beclin1. In particular, miR-1307 enhances the expression of PAK2, PLK1, PRKAR2A, MYBL1, and Trim44 and inhibits the expression of Sash1 and Smad5 via autophagy. Our observations suggest that miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway.
format	article
author	Sijie Xie Xiaoxue Jiang Rushi Qin Shuting Song Yanan Lu Liyan Wang Yingjie Chen Dongdong Lu
author_facet	Sijie Xie Xiaoxue Jiang Rushi Qin Shuting Song Yanan Lu Liyan Wang Yingjie Chen Dongdong Lu
author_sort	Sijie Xie
title	miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
title_short	miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
title_full	miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
title_fullStr	miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
title_full_unstemmed	miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
title_sort	mir-1307 promotes hepatocarcinogenesis by calr-ostc-endoplasmic reticulum protein folding pathway
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9a6b876f028443e084d27fbf4aa19d78
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_version_	1718419557054414848

miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway

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