Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol

Abstract A biofilm, a community of microorganisms, is highly resistant to antibiotics, resulting in massive losses in various areas. We herein present a strategy to remove Streptococcus mutans biofilms through a spontaneous exfoliation by the synergistic effect between zwitterion and sugar alcohols....

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Autores principales:	Jong Hyun Lim, Sang-Hun Song, Hyun-Sub Park, Jeong Rae Lee, Sang-Min Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a7adc406ec544babecc898caebf2857
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spelling	oai:doaj.org-article:9a7adc406ec544babecc898caebf28572021-12-02T12:31:48ZSpontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol10.1038/s41598-017-08558-x2045-2322https://doaj.org/article/9a7adc406ec544babecc898caebf28572017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08558-xhttps://doaj.org/toc/2045-2322Abstract A biofilm, a community of microorganisms, is highly resistant to antibiotics, resulting in massive losses in various areas. We herein present a strategy to remove Streptococcus mutans biofilms through a spontaneous exfoliation by the synergistic effect between zwitterion and sugar alcohols. It is assumed that the anionic site of zwitterion can be coupled with sugar alcohols and the cationic site remains in the state of lacking electrons. The cationic site allows the complexes to be delivered to negatively charged exopolysaccharides of biofilms. This strategy facilitates a significant increase in the ability of sugar alcohols to disperse aggregated exopolysaccharides. In this work, it was demonstrated that the mixture of betaine and erythritol existed as a complex in water and that the complex induced a spontaneous detachment of biofilms from the surface to which the biofilms had been adhered. This detachment resulted from a reduction in adhesive forces of the biofilms due to an increase in solubility of bacterial exopolysaccharides. The effects triggered by the formation of complex between zwitterion and sugar alcohol provide a simple and safe way to remove biofilms without antibiotics and physical forces.Jong Hyun LimSang-Hun SongHyun-Sub ParkJeong Rae LeeSang-Min LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Hyun Lim Sang-Hun Song Hyun-Sub Park Jeong Rae Lee Sang-Min Lee Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
description	Abstract A biofilm, a community of microorganisms, is highly resistant to antibiotics, resulting in massive losses in various areas. We herein present a strategy to remove Streptococcus mutans biofilms through a spontaneous exfoliation by the synergistic effect between zwitterion and sugar alcohols. It is assumed that the anionic site of zwitterion can be coupled with sugar alcohols and the cationic site remains in the state of lacking electrons. The cationic site allows the complexes to be delivered to negatively charged exopolysaccharides of biofilms. This strategy facilitates a significant increase in the ability of sugar alcohols to disperse aggregated exopolysaccharides. In this work, it was demonstrated that the mixture of betaine and erythritol existed as a complex in water and that the complex induced a spontaneous detachment of biofilms from the surface to which the biofilms had been adhered. This detachment resulted from a reduction in adhesive forces of the biofilms due to an increase in solubility of bacterial exopolysaccharides. The effects triggered by the formation of complex between zwitterion and sugar alcohol provide a simple and safe way to remove biofilms without antibiotics and physical forces.
format	article
author	Jong Hyun Lim Sang-Hun Song Hyun-Sub Park Jeong Rae Lee Sang-Min Lee
author_facet	Jong Hyun Lim Sang-Hun Song Hyun-Sub Park Jeong Rae Lee Sang-Min Lee
author_sort	Jong Hyun Lim
title	Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
title_short	Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
title_full	Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
title_fullStr	Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
title_full_unstemmed	Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
title_sort	spontaneous detachment of streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9a7adc406ec544babecc898caebf2857
work_keys_str_mv	AT jonghyunlim spontaneousdetachmentofstreptococcusmutansbiofilmbysynergisticeffectbetweenzwitterionandsugaralcohol AT sanghunsong spontaneousdetachmentofstreptococcusmutansbiofilmbysynergisticeffectbetweenzwitterionandsugaralcohol AT hyunsubpark spontaneousdetachmentofstreptococcusmutansbiofilmbysynergisticeffectbetweenzwitterionandsugaralcohol AT jeongraelee spontaneousdetachmentofstreptococcusmutansbiofilmbysynergisticeffectbetweenzwitterionandsugaralcohol AT sangminlee spontaneousdetachmentofstreptococcusmutansbiofilmbysynergisticeffectbetweenzwitterionandsugaralcohol
_version_	1718394294408052736

Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol

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