Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

Vertebrate adaptation to high-altitude life has been extensively investigated, while invertebrates are less well-studied. Here, the authors find signals of adaptive evolution in genomes of migratory locusts from the Tibetan Plateau, and implicate a PTPN1 coding mutation in their hypoxia response.

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Autores principales:	Ding Ding, Guangjian Liu, Li Hou, Wanying Gui, Bing Chen, Le Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a7b5eabb66943b2a0d6ac4f969f1cde
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spelling	oai:doaj.org-article:9a7b5eabb66943b2a0d6ac4f969f1cde2021-12-02T15:34:29ZGenetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts10.1038/s41467-018-07529-82041-1723https://doaj.org/article/9a7b5eabb66943b2a0d6ac4f969f1cde2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07529-8https://doaj.org/toc/2041-1723Vertebrate adaptation to high-altitude life has been extensively investigated, while invertebrates are less well-studied. Here, the authors find signals of adaptive evolution in genomes of migratory locusts from the Tibetan Plateau, and implicate a PTPN1 coding mutation in their hypoxia response.Ding DingGuangjian LiuLi HouWanying GuiBing ChenLe KangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ding Ding Guangjian Liu Li Hou Wanying Gui Bing Chen Le Kang Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
description	Vertebrate adaptation to high-altitude life has been extensively investigated, while invertebrates are less well-studied. Here, the authors find signals of adaptive evolution in genomes of migratory locusts from the Tibetan Plateau, and implicate a PTPN1 coding mutation in their hypoxia response.
format	article
author	Ding Ding Guangjian Liu Li Hou Wanying Gui Bing Chen Le Kang
author_facet	Ding Ding Guangjian Liu Li Hou Wanying Gui Bing Chen Le Kang
author_sort	Ding Ding
title	Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
title_short	Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
title_full	Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
title_fullStr	Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
title_full_unstemmed	Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
title_sort	genetic variation in ptpn1 contributes to metabolic adaptation to high-altitude hypoxia in tibetan migratory locusts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9a7b5eabb66943b2a0d6ac4f969f1cde
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Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

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