Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder

Wen-Jiun Chou,1 Liang-Jen Wang,1 Chien-Ho Lin,2 Sun-Yuan Liang,3 Vincent Chin-Hung Chen,4 Yuh-Ming Hou,5 Rong-Rong Huang,6 Miao-Chun Chou,1 Chi-Yung Shang,7 Chi-Pui Ho,6 Meng-Chuan Lai8 1Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University...

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Autores principales:	Chou WJ, Wang LJ, Lin CH, Liang SY, Chen VCH, Hou YM, Huang RR, Chou MC, Shang CY, Ho CP, Lai MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ADHD central nervous system stimulant drug adherence family social adjustment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9a7c083839914ef18ad7c069ce2d7019
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spelling	oai:doaj.org-article:9a7c083839914ef18ad7c069ce2d70192021-12-02T07:42:22ZSocial adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder1178-2021https://doaj.org/article/9a7c083839914ef18ad7c069ce2d70192018-10-01T00:00:00Zhttps://www.dovepress.com/social-adjustment-and-family-function-after-drug-switch-from-ir--methy-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wen-Jiun Chou,1 Liang-Jen Wang,1 Chien-Ho Lin,2 Sun-Yuan Liang,3 Vincent Chin-Hung Chen,4 Yuh-Ming Hou,5 Rong-Rong Huang,6 Miao-Chun Chou,1 Chi-Yung Shang,7 Chi-Pui Ho,6 Meng-Chuan Lai8 1Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 2Department of Psychiatry, Chimei Medical Center, Tainan, 3Department of Psychiatry, Changhua Hospital, Changhua, 4Department of Psychiatry, Chang Gung Memorial Hospital and University, 5Chia-Yi Christian Hospital, Chiayi, 6Department of Child and Adolescent Psychiatry, Kai-Suan Psychiatric Hospital, Kaohsiung, 7Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; 8Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Purpose: This prospective, single-arm, open-label, 8-week, multicenter study investigated the effectiveness of switching from immediate-release methylphenidate (IR-MPH) to osmotic controlled-release methylphenidate (OROS-MPH) in patients with attention-deficit/hyperactivity disorder (ADHD).Patients and methods: Overall, 296 patients with ADHD (mean age: 9.5 years) already on IR-MPH treatment were enrolled. Upon enrollment, a flexible dose of OROS-MPH was administered, replacing IR-MPH. Patients were assessed at baseline and weeks 2, 4, and 8 using the Swanson, Nolan, and Pelham version IV scale (SNAP-IV) and the Clinical Global Impression for ADHD symptoms. The Social Adjustment Inventory for Children and Adolescents assessed social functions, and the Chinese Health Questionnaire (CHQ) and Family Adaptation, Partnership, Growth, Affection, and Resolve evaluated parental and family functions.Results: Switching from IR-MPH to OROS-MPH yielded significant improvements in all ADHD symptoms, as rated by parents, teachers (SNAP-IV), and study investigators (Clinical Global Impression). CHQ scores and all Social Adjustment Inventory for Children and Adolescents subscores except spare time scores improved significantly. Patients with poor IR-MPH adherence had greater improvements in teacher-rated SNAP-IV and mothers’ mental health (CHQ) after switching. Conclusion: Switching from IR-MPH to OROS-MPH improved patients’ behavioral ADHD symptoms and social adjustment, and mental health of patients’ mothers. This was most evident in patients who previously exhibited poor IR-MPH adherence. Keywords: ADHD, central nervous system stimulant, drug adherence, family, social adjustmentChou WJWang LJLin CHLiang SYChen VCHHou YMHuang RRChou MCShang CYHo CPLai MCDove Medical PressarticleADHDcentral nervous system stimulantdrug adherencefamilysocial adjustmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2783-2791 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ADHD central nervous system stimulant drug adherence family social adjustment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ADHD central nervous system stimulant drug adherence family social adjustment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chou WJ Wang LJ Lin CH Liang SY Chen VCH Hou YM Huang RR Chou MC Shang CY Ho CP Lai MC Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
description	Wen-Jiun Chou,1 Liang-Jen Wang,1 Chien-Ho Lin,2 Sun-Yuan Liang,3 Vincent Chin-Hung Chen,4 Yuh-Ming Hou,5 Rong-Rong Huang,6 Miao-Chun Chou,1 Chi-Yung Shang,7 Chi-Pui Ho,6 Meng-Chuan Lai8 1Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 2Department of Psychiatry, Chimei Medical Center, Tainan, 3Department of Psychiatry, Changhua Hospital, Changhua, 4Department of Psychiatry, Chang Gung Memorial Hospital and University, 5Chia-Yi Christian Hospital, Chiayi, 6Department of Child and Adolescent Psychiatry, Kai-Suan Psychiatric Hospital, Kaohsiung, 7Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; 8Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Purpose: This prospective, single-arm, open-label, 8-week, multicenter study investigated the effectiveness of switching from immediate-release methylphenidate (IR-MPH) to osmotic controlled-release methylphenidate (OROS-MPH) in patients with attention-deficit/hyperactivity disorder (ADHD).Patients and methods: Overall, 296 patients with ADHD (mean age: 9.5 years) already on IR-MPH treatment were enrolled. Upon enrollment, a flexible dose of OROS-MPH was administered, replacing IR-MPH. Patients were assessed at baseline and weeks 2, 4, and 8 using the Swanson, Nolan, and Pelham version IV scale (SNAP-IV) and the Clinical Global Impression for ADHD symptoms. The Social Adjustment Inventory for Children and Adolescents assessed social functions, and the Chinese Health Questionnaire (CHQ) and Family Adaptation, Partnership, Growth, Affection, and Resolve evaluated parental and family functions.Results: Switching from IR-MPH to OROS-MPH yielded significant improvements in all ADHD symptoms, as rated by parents, teachers (SNAP-IV), and study investigators (Clinical Global Impression). CHQ scores and all Social Adjustment Inventory for Children and Adolescents subscores except spare time scores improved significantly. Patients with poor IR-MPH adherence had greater improvements in teacher-rated SNAP-IV and mothers’ mental health (CHQ) after switching. Conclusion: Switching from IR-MPH to OROS-MPH improved patients’ behavioral ADHD symptoms and social adjustment, and mental health of patients’ mothers. This was most evident in patients who previously exhibited poor IR-MPH adherence. Keywords: ADHD, central nervous system stimulant, drug adherence, family, social adjustment
format	article
author	Chou WJ Wang LJ Lin CH Liang SY Chen VCH Hou YM Huang RR Chou MC Shang CY Ho CP Lai MC
author_facet	Chou WJ Wang LJ Lin CH Liang SY Chen VCH Hou YM Huang RR Chou MC Shang CY Ho CP Lai MC
author_sort	Chou WJ
title	Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
title_short	Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
title_full	Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
title_fullStr	Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
title_full_unstemmed	Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
title_sort	social adjustment and family function after drug switch from ir -methylphenidate to oros-methylphenidate in patients with attention-deficit/hyperactivity disorder
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9a7c083839914ef18ad7c069ce2d7019
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Social adjustment and family function after drug switch from IR -methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder

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