Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.

Recent studies in animal models of Alzheimer's disease (AD) show that amyloid-beta (Aβ) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this study was to analyze whether depletion of aggregates from an AD brain supp...

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Autores principales:	Claudia Duran-Aniotz, Rodrigo Morales, Ines Moreno-Gonzalez, Ping Ping Hu, Joseph Fedynyshyn, Claudio Soto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a7e6cd0f02841ca81b6223878587884
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spelling	oai:doaj.org-article:9a7e6cd0f02841ca81b62238785878842021-11-18T08:32:43ZAggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.1932-620310.1371/journal.pone.0089014https://doaj.org/article/9a7e6cd0f02841ca81b62238785878842014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24533166/?tool=EBIhttps://doaj.org/toc/1932-6203Recent studies in animal models of Alzheimer's disease (AD) show that amyloid-beta (Aβ) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this study was to analyze whether depletion of aggregates from an AD brain suppresses its in vivo "seeding" capability. Removal of aggregates was performed by using the Aggregate Specific Reagent 1 (ASR1) compound which has been previously described to specifically bind misfolded species. Our results show that pre-treatment with ASR1-coupled magnetic beads reduces the in vivo misfolding inducing capability of an AD brain extract. These findings shed light respect to the active principle responsible for the prion-like spreading of Alzheimer's amyloid pathology and open the possibility of using seeds-capturing reagents as a promising target for AD treatment.Claudia Duran-AniotzRodrigo MoralesInes Moreno-GonzalezPing Ping HuJoseph FedynyshynClaudio SotoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89014 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claudia Duran-Aniotz Rodrigo Morales Ines Moreno-Gonzalez Ping Ping Hu Joseph Fedynyshyn Claudio Soto Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
description	Recent studies in animal models of Alzheimer's disease (AD) show that amyloid-beta (Aβ) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this study was to analyze whether depletion of aggregates from an AD brain suppresses its in vivo "seeding" capability. Removal of aggregates was performed by using the Aggregate Specific Reagent 1 (ASR1) compound which has been previously described to specifically bind misfolded species. Our results show that pre-treatment with ASR1-coupled magnetic beads reduces the in vivo misfolding inducing capability of an AD brain extract. These findings shed light respect to the active principle responsible for the prion-like spreading of Alzheimer's amyloid pathology and open the possibility of using seeds-capturing reagents as a promising target for AD treatment.
format	article
author	Claudia Duran-Aniotz Rodrigo Morales Ines Moreno-Gonzalez Ping Ping Hu Joseph Fedynyshyn Claudio Soto
author_facet	Claudia Duran-Aniotz Rodrigo Morales Ines Moreno-Gonzalez Ping Ping Hu Joseph Fedynyshyn Claudio Soto
author_sort	Claudia Duran-Aniotz
title	Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
title_short	Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
title_full	Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
title_fullStr	Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
title_full_unstemmed	Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
title_sort	aggregate-depleted brain fails to induce aβ deposition in a mouse model of alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/9a7e6cd0f02841ca81b6223878587884
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Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.

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