20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion vi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a7ee26cbe794bc5b4667eb9d97b5e93
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a7ee26cbe794bc5b4667eb9d97b5e93
record_format	dspace
spelling	oai:doaj.org-article:9a7ee26cbe794bc5b4667eb9d97b5e932021-12-02T17:32:02Z20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR110.1038/s41467-017-02539-42041-1723https://doaj.org/article/9a7ee26cbe794bc5b4667eb9d97b5e932018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02539-4https://doaj.org/toc/2041-1723FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion via FFAR1 activation.Sorin TunaruRemy BonnavionIsabell BrandenburgerJens PreussnerDominique ThomasKlaus ScholichStefan OffermannsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sorin Tunaru Remy Bonnavion Isabell Brandenburger Jens Preussner Dominique Thomas Klaus Scholich Stefan Offermanns 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
description	FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion via FFAR1 activation.
format	article
author	Sorin Tunaru Remy Bonnavion Isabell Brandenburger Jens Preussner Dominique Thomas Klaus Scholich Stefan Offermanns
author_facet	Sorin Tunaru Remy Bonnavion Isabell Brandenburger Jens Preussner Dominique Thomas Klaus Scholich Stefan Offermanns
author_sort	Sorin Tunaru
title	20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
title_short	20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
title_full	20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
title_fullStr	20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
title_full_unstemmed	20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
title_sort	20-hete promotes glucose-stimulated insulin secretion in an autocrine manner through ffar1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9a7ee26cbe794bc5b4667eb9d97b5e93
work_keys_str_mv	AT sorintunaru 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1 AT remybonnavion 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1 AT isabellbrandenburger 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1 AT jenspreussner 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1 AT dominiquethomas 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1 AT klausscholich 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1 AT stefanoffermanns 20hetepromotesglucosestimulatedinsulinsecretioninanautocrinemannerthroughffar1
_version_	1718380443721531392

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

Ejemplares similares