20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion vi...

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Autores principales: Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/9a7ee26cbe794bc5b4667eb9d97b5e93
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