Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women

Abstract Fibromyalgia syndrome (FM) is a multifactorial disorder whose pathogenesis and diagnosis are poorly understood. This study investigated differential serum proteome profiles in patients with FM and healthy pain-free controls and explored the association between serum proteome and clinical pr...

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Autores principales:	Chia-Li Han, Yung-Ching Sheng, San-Yuan Wang, Yi-Hsuan Chen, Jiunn-Horng Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a8092f266534e349c2fd138ef95d9c5
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spelling	oai:doaj.org-article:9a8092f266534e349c2fd138ef95d9c52021-12-02T16:26:22ZSerum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women10.1038/s41598-020-69271-w2045-2322https://doaj.org/article/9a8092f266534e349c2fd138ef95d9c52020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69271-whttps://doaj.org/toc/2045-2322Abstract Fibromyalgia syndrome (FM) is a multifactorial disorder whose pathogenesis and diagnosis are poorly understood. This study investigated differential serum proteome profiles in patients with FM and healthy pain-free controls and explored the association between serum proteome and clinical profiles in patients with FM. Twenty patients with FM (according to the American College of Rheumatology criteria, 2010) and 20 healthy pain-free controls were recruited for optimized quantitative serum proteomics analysis. The levels of pain, pressure pain threshold, sleep, anxiety, depression, and functional status were evaluated for patients with FM. We identified 22 proteins differentially expressed in FM when compared with healthy pain-free controls and propose a panel of methyltransferase-like 18 (METTL18), immunoglobulin lambda variable 3–25 (IGLV3–25), interleukin-1 receptor accessory protein (IL1RAP), and IGHV1OR21-1 for differentiating FM from controls by using a decision tree model (accuracy: 0.97). In addition, we noted several proteins involved in coagulation and inflammation pathways with distinct expression patterns in patients with FM. Novel proteins were also observed to be correlated with the levels of pain, depression, and dysautonomia in patients with FM. We suggest that upregulated inflammation can play a major role in the pathomechanism of FM. The differentially expressed proteins identified may serve as useful biomarkers for diagnosis and evaluation of FM in the future.Chia-Li HanYung-Ching ShengSan-Yuan WangYi-Hsuan ChenJiunn-Horng KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Li Han Yung-Ching Sheng San-Yuan Wang Yi-Hsuan Chen Jiunn-Horng Kang Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
description	Abstract Fibromyalgia syndrome (FM) is a multifactorial disorder whose pathogenesis and diagnosis are poorly understood. This study investigated differential serum proteome profiles in patients with FM and healthy pain-free controls and explored the association between serum proteome and clinical profiles in patients with FM. Twenty patients with FM (according to the American College of Rheumatology criteria, 2010) and 20 healthy pain-free controls were recruited for optimized quantitative serum proteomics analysis. The levels of pain, pressure pain threshold, sleep, anxiety, depression, and functional status were evaluated for patients with FM. We identified 22 proteins differentially expressed in FM when compared with healthy pain-free controls and propose a panel of methyltransferase-like 18 (METTL18), immunoglobulin lambda variable 3–25 (IGLV3–25), interleukin-1 receptor accessory protein (IL1RAP), and IGHV1OR21-1 for differentiating FM from controls by using a decision tree model (accuracy: 0.97). In addition, we noted several proteins involved in coagulation and inflammation pathways with distinct expression patterns in patients with FM. Novel proteins were also observed to be correlated with the levels of pain, depression, and dysautonomia in patients with FM. We suggest that upregulated inflammation can play a major role in the pathomechanism of FM. The differentially expressed proteins identified may serve as useful biomarkers for diagnosis and evaluation of FM in the future.
format	article
author	Chia-Li Han Yung-Ching Sheng San-Yuan Wang Yi-Hsuan Chen Jiunn-Horng Kang
author_facet	Chia-Li Han Yung-Ching Sheng San-Yuan Wang Yi-Hsuan Chen Jiunn-Horng Kang
author_sort	Chia-Li Han
title	Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
title_short	Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
title_full	Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
title_fullStr	Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
title_full_unstemmed	Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
title_sort	serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9a8092f266534e349c2fd138ef95d9c5
work_keys_str_mv	AT chialihan serumproteomeprofilesrevealeddysregulatedproteinsandmechanismsassociatedwithfibromyalgiasyndromeinwomen AT yungchingsheng serumproteomeprofilesrevealeddysregulatedproteinsandmechanismsassociatedwithfibromyalgiasyndromeinwomen AT sanyuanwang serumproteomeprofilesrevealeddysregulatedproteinsandmechanismsassociatedwithfibromyalgiasyndromeinwomen AT yihsuanchen serumproteomeprofilesrevealeddysregulatedproteinsandmechanismsassociatedwithfibromyalgiasyndromeinwomen AT jiunnhorngkang serumproteomeprofilesrevealeddysregulatedproteinsandmechanismsassociatedwithfibromyalgiasyndromeinwomen
_version_	1718384069938511872

Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women

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