Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma

BACKGROUND AND OBJECTIVE: Colorectal cancer is the major and cause of morbidity and mortality throughout the world. Loss of activity of P53 and P21 (WAF1) proteins that belong to the cell cycle regulation family of protein, seems to be important regulatory mechanism of carcinogenesis in colorectal c...

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Autores principales:	M Jahantigh, B Narouie, E Sheikhi Ghayur, A Davarian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	colorectal cancer protein p53 protein p21 immunohistochemistry (ihc) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9a84bd470dd6496b8f92fa435e4e1693
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spelling	oai:doaj.org-article:9a84bd470dd6496b8f92fa435e4e16932021-11-10T08:53:02ZCorrelation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma1561-41072251-7170https://doaj.org/article/9a84bd470dd6496b8f92fa435e4e16932012-03-01T00:00:00Zhttp://jbums.org/article-1-4036-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Colorectal cancer is the major and cause of morbidity and mortality throughout the world. Loss of activity of P53 and P21 (WAF1) proteins that belong to the cell cycle regulation family of protein, seems to be important regulatory mechanism of carcinogenesis in colorectal cancer and affected prognosis and resistance to chemotherapy. P21 expressed in P53-dependent and independent pathway. This study was designed to assess P53 and P21 frequency and their correlation with pathological parameters in colorectal adenocarcinoma.METHODS: This analytical study was done on 70 paraffin preserved colorectal adenocarcinoma samples of patients in Zahedan, Iran who underwent colectomy from 2003 to 2010. Tissue slice was stained and evaluated by method of immunohistochemistry for P53 and P21 protein and evaluated. FINDINGS: P53 was expressed in 37( 52.9%) patients and P21 was expressed in 33(47.1%). No correlation was found between P53 overexpression and P21 with pathological variables. P21 had a statistically significant association with tumor differentiation (p=0.02). The high frequency of P21 was seen in good differentiated tumors.CONCLUSION: The results of the study show that P53 mutation plays an important role in the development of colorectal cancer. No correlation between P21 expression and P53 statue supports the theory that P21 induction occurs mostly in P53 independent pathway in colorectal cancer.M JahantighB NarouieE Sheikhi GhayurA DavarianBabol University of Medical Sciencesarticlecolorectal cancerprotein p53protein p21immunohistochemistry (ihc)MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 2, Pp 47-52 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	colorectal cancer protein p53 protein p21 immunohistochemistry (ihc) Medicine R Medicine (General) R5-920
spellingShingle	colorectal cancer protein p53 protein p21 immunohistochemistry (ihc) Medicine R Medicine (General) R5-920 M Jahantigh B Narouie E Sheikhi Ghayur A Davarian Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma
description	BACKGROUND AND OBJECTIVE: Colorectal cancer is the major and cause of morbidity and mortality throughout the world. Loss of activity of P53 and P21 (WAF1) proteins that belong to the cell cycle regulation family of protein, seems to be important regulatory mechanism of carcinogenesis in colorectal cancer and affected prognosis and resistance to chemotherapy. P21 expressed in P53-dependent and independent pathway. This study was designed to assess P53 and P21 frequency and their correlation with pathological parameters in colorectal adenocarcinoma.METHODS: This analytical study was done on 70 paraffin preserved colorectal adenocarcinoma samples of patients in Zahedan, Iran who underwent colectomy from 2003 to 2010. Tissue slice was stained and evaluated by method of immunohistochemistry for P53 and P21 protein and evaluated. FINDINGS: P53 was expressed in 37( 52.9%) patients and P21 was expressed in 33(47.1%). No correlation was found between P53 overexpression and P21 with pathological variables. P21 had a statistically significant association with tumor differentiation (p=0.02). The high frequency of P21 was seen in good differentiated tumors.CONCLUSION: The results of the study show that P53 mutation plays an important role in the development of colorectal cancer. No correlation between P21 expression and P53 statue supports the theory that P21 induction occurs mostly in P53 independent pathway in colorectal cancer.
format	article
author	M Jahantigh B Narouie E Sheikhi Ghayur A Davarian
author_facet	M Jahantigh B Narouie E Sheikhi Ghayur A Davarian
author_sort	M Jahantigh
title	Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma
title_short	Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma
title_full	Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma
title_fullStr	Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma
title_full_unstemmed	Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma
title_sort	correlation between frequency of p53 and p21 proteins with pathological parameters in colorectal adenocarcinoma
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/9a84bd470dd6496b8f92fa435e4e1693
work_keys_str_mv	AT mjahantigh correlationbetweenfrequencyofp53andp21proteinswithpathologicalparametersincolorectaladenocarcinoma AT bnarouie correlationbetweenfrequencyofp53andp21proteinswithpathologicalparametersincolorectaladenocarcinoma AT esheikhighayur correlationbetweenfrequencyofp53andp21proteinswithpathologicalparametersincolorectaladenocarcinoma AT adavarian correlationbetweenfrequencyofp53andp21proteinswithpathologicalparametersincolorectaladenocarcinoma
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Correlation between Frequency of P53 and P21 Proteins with Pathological Parameters in Colorectal Adenocarcinoma

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