Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study

Abstract Background Combatting antimicrobial resistance requires a One Health approach to antimicrobial stewardship including antimicrobial drug (AMD) use evaluation. Current veterinary AMD prescribing data are limited. Objectives To quantify companion animal AMD prescribing in primary care and spec...

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Autores principales:	Robert Goggs, Julie M. Menard, Craig Altier, Kevin J. Cummings, Megan E. Jacob, Denise F. Lalonde‐Paul, Mark G. Papich, Keri N. Norman, Virginia R. Fajt, H. Morgan Scott, Sara D. Lawhon
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	antibiotic antimicrobial drug antimicrobial prescribing practices antimicrobial prescription Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/9a85320ae6dc4ba49b07e802c9975241
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spelling	oai:doaj.org-article:9a85320ae6dc4ba49b07e802c99752412021-11-30T17:01:04ZPatterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study1939-16760891-664010.1111/jvim.16136https://doaj.org/article/9a85320ae6dc4ba49b07e802c99752412021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16136https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Combatting antimicrobial resistance requires a One Health approach to antimicrobial stewardship including antimicrobial drug (AMD) use evaluation. Current veterinary AMD prescribing data are limited. Objectives To quantify companion animal AMD prescribing in primary care and specialty practice across 3 academic veterinary hospitals with particular focus on third‐generation cephalosporins, fluoroquinolones, and carbapenems. Animals Dogs and cats presented to 3 academic veterinary hospitals from 2012 to 2017. Methods In this retrospective study, AMD prescribing data from 2012 to 2017 were extracted from electronic medical records at each hospital and prescriptions classified by service type: primary care, specialty practice or Emergency/Critical Care (ECC). Hospital‐level AMD prescribing data were summarized by species, service type, AMD class, and drug. Multivariable logistic full‐factorial regression models were used to estimate hospital, year, species, and service‐type effects on AMD prescribing. Estimated marginal means and confidence intervals were plotted over time. Results The probability of systemic AMD prescribing for any indication ranged between 0.15 and 0.28 and was higher for dogs than cats (P < .05) apart from 2017 at hospital 1. Animals presented to primary care were least likely to receive AMDs (dogs 0.03‐0.15, cats 0.03‐0.18). The most commonly prescribed AMD classes were aminopenicillins/β‐lactamase inhibitors (0.02‐0.15), first‐generation cephalosporins (0.00‐0.09), fluoroquinolones (0.00‐0.04), nitroimidazoles (0.01‐0.06), and tetracyclines (0.00‐0.03). Among the highest priority classes, fluoroquinolones (dogs 0.00‐0.09, cats 0.00‐0.08) and third‐generation cephalosporins (dogs 0.00‐0.04, cats 0.00‐0.05) were most frequently prescribed. Conclusions and Clinical Importance Antimicrobial drug prescribing frequencies were comparable to previous studies. Additional stewardship efforts might focus on fluoroquinolones and third‐generation cephalosporins.Robert GoggsJulie M. MenardCraig AltierKevin J. CummingsMegan E. JacobDenise F. Lalonde‐PaulMark G. PapichKeri N. NormanVirginia R. FajtH. Morgan ScottSara D. LawhonWileyarticleantibioticantimicrobial drugantimicrobial prescribing practicesantimicrobial prescriptionVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1496-1508 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic antimicrobial drug antimicrobial prescribing practices antimicrobial prescription Veterinary medicine SF600-1100
spellingShingle	antibiotic antimicrobial drug antimicrobial prescribing practices antimicrobial prescription Veterinary medicine SF600-1100 Robert Goggs Julie M. Menard Craig Altier Kevin J. Cummings Megan E. Jacob Denise F. Lalonde‐Paul Mark G. Papich Keri N. Norman Virginia R. Fajt H. Morgan Scott Sara D. Lawhon Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study
description	Abstract Background Combatting antimicrobial resistance requires a One Health approach to antimicrobial stewardship including antimicrobial drug (AMD) use evaluation. Current veterinary AMD prescribing data are limited. Objectives To quantify companion animal AMD prescribing in primary care and specialty practice across 3 academic veterinary hospitals with particular focus on third‐generation cephalosporins, fluoroquinolones, and carbapenems. Animals Dogs and cats presented to 3 academic veterinary hospitals from 2012 to 2017. Methods In this retrospective study, AMD prescribing data from 2012 to 2017 were extracted from electronic medical records at each hospital and prescriptions classified by service type: primary care, specialty practice or Emergency/Critical Care (ECC). Hospital‐level AMD prescribing data were summarized by species, service type, AMD class, and drug. Multivariable logistic full‐factorial regression models were used to estimate hospital, year, species, and service‐type effects on AMD prescribing. Estimated marginal means and confidence intervals were plotted over time. Results The probability of systemic AMD prescribing for any indication ranged between 0.15 and 0.28 and was higher for dogs than cats (P < .05) apart from 2017 at hospital 1. Animals presented to primary care were least likely to receive AMDs (dogs 0.03‐0.15, cats 0.03‐0.18). The most commonly prescribed AMD classes were aminopenicillins/β‐lactamase inhibitors (0.02‐0.15), first‐generation cephalosporins (0.00‐0.09), fluoroquinolones (0.00‐0.04), nitroimidazoles (0.01‐0.06), and tetracyclines (0.00‐0.03). Among the highest priority classes, fluoroquinolones (dogs 0.00‐0.09, cats 0.00‐0.08) and third‐generation cephalosporins (dogs 0.00‐0.04, cats 0.00‐0.05) were most frequently prescribed. Conclusions and Clinical Importance Antimicrobial drug prescribing frequencies were comparable to previous studies. Additional stewardship efforts might focus on fluoroquinolones and third‐generation cephalosporins.
format	article
author	Robert Goggs Julie M. Menard Craig Altier Kevin J. Cummings Megan E. Jacob Denise F. Lalonde‐Paul Mark G. Papich Keri N. Norman Virginia R. Fajt H. Morgan Scott Sara D. Lawhon
author_facet	Robert Goggs Julie M. Menard Craig Altier Kevin J. Cummings Megan E. Jacob Denise F. Lalonde‐Paul Mark G. Papich Keri N. Norman Virginia R. Fajt H. Morgan Scott Sara D. Lawhon
author_sort	Robert Goggs
title	Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study
title_short	Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study
title_full	Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study
title_fullStr	Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study
title_full_unstemmed	Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study
title_sort	patterns of antimicrobial drug use in veterinary primary care and specialty practice: a 6‐year multi‐institution study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/9a85320ae6dc4ba49b07e802c9975241
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Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6‐year multi‐institution study

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