Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

The hepatopancreatic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for their lineage specification is unclear. Here, the authors reveal that Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.

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Auteurs principaux:	Danhua Zhang, Keith P. Gates, Lindsey Barske, Guangliang Wang, Joseph J. Lancman, Xin-Xin I. Zeng, Megan Groff, Kasper Wang, Michael J. Parsons, J. Gage Crump, P. Duc Si Dong
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9a869d75f80549c8a2ff75e1bc7269a8
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spelling	oai:doaj.org-article:9a869d75f80549c8a2ff75e1bc7269a82021-12-02T14:42:37ZEndoderm Jagged induces liver and pancreas duct lineage in zebrafish10.1038/s41467-017-00666-62041-1723https://doaj.org/article/9a869d75f80549c8a2ff75e1bc7269a82017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00666-6https://doaj.org/toc/2041-1723The hepatopancreatic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for their lineage specification is unclear. Here, the authors reveal that Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.Danhua ZhangKeith P. GatesLindsey BarskeGuangliang WangJoseph J. LancmanXin-Xin I. ZengMegan GroffKasper WangMichael J. ParsonsJ. Gage CrumpP. Duc Si DongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Danhua Zhang Keith P. Gates Lindsey Barske Guangliang Wang Joseph J. Lancman Xin-Xin I. Zeng Megan Groff Kasper Wang Michael J. Parsons J. Gage Crump P. Duc Si Dong Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
description	The hepatopancreatic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for their lineage specification is unclear. Here, the authors reveal that Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
format	article
author	Danhua Zhang Keith P. Gates Lindsey Barske Guangliang Wang Joseph J. Lancman Xin-Xin I. Zeng Megan Groff Kasper Wang Michael J. Parsons J. Gage Crump P. Duc Si Dong
author_facet	Danhua Zhang Keith P. Gates Lindsey Barske Guangliang Wang Joseph J. Lancman Xin-Xin I. Zeng Megan Groff Kasper Wang Michael J. Parsons J. Gage Crump P. Duc Si Dong
author_sort	Danhua Zhang
title	Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
title_short	Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
title_full	Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
title_fullStr	Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
title_full_unstemmed	Endoderm Jagged induces liver and pancreas duct lineage in zebrafish
title_sort	endoderm jagged induces liver and pancreas duct lineage in zebrafish
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9a869d75f80549c8a2ff75e1bc7269a8
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Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

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