Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

Several inhibitors of the electron transport chain (ETC) are active against Mycobacterium tuberculosis. Here, Lamprecht et al. show that a combination of known inhibitors (bedaquiline, Q203 and clofazimine) displays synergistic effects on the M. tuberculosis ETC and improved antibacterial activity i...

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Autores principales:	Dirk A. Lamprecht, Peter M. Finin, Md. Aejazur Rahman, Bridgette M. Cumming, Shannon L. Russell, Surendranadha R. Jonnala, John H. Adamson, Adrie J. C. Steyn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a86dfe38a8246cd9d09bf2f836eeae4
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spelling	oai:doaj.org-article:9a86dfe38a8246cd9d09bf2f836eeae42021-12-02T14:40:15ZTurning the respiratory flexibility of Mycobacterium tuberculosis against itself10.1038/ncomms123932041-1723https://doaj.org/article/9a86dfe38a8246cd9d09bf2f836eeae42016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12393https://doaj.org/toc/2041-1723Several inhibitors of the electron transport chain (ETC) are active against Mycobacterium tuberculosis. Here, Lamprecht et al. show that a combination of known inhibitors (bedaquiline, Q203 and clofazimine) displays synergistic effects on the M. tuberculosis ETC and improved antibacterial activity in vitro.Dirk A. LamprechtPeter M. FininMd. Aejazur RahmanBridgette M. CummingShannon L. RussellSurendranadha R. JonnalaJohn H. AdamsonAdrie J. C. SteynNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dirk A. Lamprecht Peter M. Finin Md. Aejazur Rahman Bridgette M. Cumming Shannon L. Russell Surendranadha R. Jonnala John H. Adamson Adrie J. C. Steyn Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
description	Several inhibitors of the electron transport chain (ETC) are active against Mycobacterium tuberculosis. Here, Lamprecht et al. show that a combination of known inhibitors (bedaquiline, Q203 and clofazimine) displays synergistic effects on the M. tuberculosis ETC and improved antibacterial activity in vitro.
format	article
author	Dirk A. Lamprecht Peter M. Finin Md. Aejazur Rahman Bridgette M. Cumming Shannon L. Russell Surendranadha R. Jonnala John H. Adamson Adrie J. C. Steyn
author_facet	Dirk A. Lamprecht Peter M. Finin Md. Aejazur Rahman Bridgette M. Cumming Shannon L. Russell Surendranadha R. Jonnala John H. Adamson Adrie J. C. Steyn
author_sort	Dirk A. Lamprecht
title	Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
title_short	Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
title_full	Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
title_fullStr	Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
title_full_unstemmed	Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
title_sort	turning the respiratory flexibility of mycobacterium tuberculosis against itself
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9a86dfe38a8246cd9d09bf2f836eeae4
work_keys_str_mv	AT dirkalamprecht turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT petermfinin turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT mdaejazurrahman turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT bridgettemcumming turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT shannonlrussell turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT surendranadharjonnala turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT johnhadamson turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself AT adriejcsteyn turningtherespiratoryflexibilityofmycobacteriumtuberculosisagainstitself
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Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

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