Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland
There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patien...
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2021
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oai:doaj.org-article:9a8bd9e256a2438da5a5557e65fbaa522021-11-25T16:49:45ZBlood Copper Levels and the Occurrence of Colorectal Cancer in Poland10.3390/biomedicines91116282227-9059https://doaj.org/article/9a8bd9e256a2438da5a5557e65fbaa522021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1628https://doaj.org/toc/2227-9059There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patients and 187 matched controls. Cases and controls were matched for sex, smoking status (yes/no) and year of birth. Among the cases, the mean blood copper level was 1031 µg/L (range 657 µg/L to 2043 µg/L) and among the controls, the mean blood copper level was 864 µg/L (range 589 µg/L to 1433 µg/L). The odds ratio for colorectal cancer for those in the highest quartile of copper level (versus the lowest) was 12.7 (95% CI: 4.98–32.3; <i>p</i> < 0.001). Of the patients with stage I–II colon cancer, 62% had a copper level in the highest quartile. A blood copper level in excess of 930 µg/L is associated with an increase in the prevalence of colorectal cancer in the Polish population and its potential use in early detection programs should be considered.Piotr BaszukWojciech MarciniakRóża DerkaczAnna JakubowskaCezary CybulskiJacek GronwaldTadeusz DębniakTomasz HuzarskiKatarzyna BiałkowskaSandra PietrzakMagdalena MuszyńskaJózef KładnySteven A. NarodJan LubińskiMarcin R. LenerMDPI AGarticlecoppercolorectal cancerbiomarkersBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1628, p 1628 (2021) |
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| collection |
DOAJ |
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EN |
| topic |
copper colorectal cancer biomarkers Biology (General) QH301-705.5 |
| spellingShingle |
copper colorectal cancer biomarkers Biology (General) QH301-705.5 Piotr Baszuk Wojciech Marciniak Róża Derkacz Anna Jakubowska Cezary Cybulski Jacek Gronwald Tadeusz Dębniak Tomasz Huzarski Katarzyna Białkowska Sandra Pietrzak Magdalena Muszyńska Józef Kładny Steven A. Narod Jan Lubiński Marcin R. Lener Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland |
| description |
There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patients and 187 matched controls. Cases and controls were matched for sex, smoking status (yes/no) and year of birth. Among the cases, the mean blood copper level was 1031 µg/L (range 657 µg/L to 2043 µg/L) and among the controls, the mean blood copper level was 864 µg/L (range 589 µg/L to 1433 µg/L). The odds ratio for colorectal cancer for those in the highest quartile of copper level (versus the lowest) was 12.7 (95% CI: 4.98–32.3; <i>p</i> < 0.001). Of the patients with stage I–II colon cancer, 62% had a copper level in the highest quartile. A blood copper level in excess of 930 µg/L is associated with an increase in the prevalence of colorectal cancer in the Polish population and its potential use in early detection programs should be considered. |
| format |
article |
| author |
Piotr Baszuk Wojciech Marciniak Róża Derkacz Anna Jakubowska Cezary Cybulski Jacek Gronwald Tadeusz Dębniak Tomasz Huzarski Katarzyna Białkowska Sandra Pietrzak Magdalena Muszyńska Józef Kładny Steven A. Narod Jan Lubiński Marcin R. Lener |
| author_facet |
Piotr Baszuk Wojciech Marciniak Róża Derkacz Anna Jakubowska Cezary Cybulski Jacek Gronwald Tadeusz Dębniak Tomasz Huzarski Katarzyna Białkowska Sandra Pietrzak Magdalena Muszyńska Józef Kładny Steven A. Narod Jan Lubiński Marcin R. Lener |
| author_sort |
Piotr Baszuk |
| title |
Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland |
| title_short |
Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland |
| title_full |
Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland |
| title_fullStr |
Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland |
| title_full_unstemmed |
Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland |
| title_sort |
blood copper levels and the occurrence of colorectal cancer in poland |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/9a8bd9e256a2438da5a5557e65fbaa52 |
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