Protein Quality Control at the Mitochondrial Surface

Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of metabolites and the formation of a signaling platf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fabian den Brave, Arushi Gupta, Thomas Becker
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondria protein sorting protein quality control Cdc48 TOM complex Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9a8d6a10ecf54c79b54f7c697e4fefbd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a8d6a10ecf54c79b54f7c697e4fefbd
record_format	dspace
spelling	oai:doaj.org-article:9a8d6a10ecf54c79b54f7c697e4fefbd2021-12-03T06:18:31ZProtein Quality Control at the Mitochondrial Surface2296-634X10.3389/fcell.2021.795685https://doaj.org/article/9a8d6a10ecf54c79b54f7c697e4fefbd2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.795685/fullhttps://doaj.org/toc/2296-634XMitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of metabolites and the formation of a signaling platform in apoptosis and innate immunity. The translocase of the outer membrane (TOM complex) forms the entry gate for the vast majority of precursor proteins that are produced on cytosolic ribosomes. Surveillance of the functionality of outer membrane proteins is critical for mitochondrial functions and biogenesis. Quality control mechanisms remove defective and mistargeted proteins from the outer membrane as well as precursor proteins that clog the TOM complex. Selective degradation of single proteins is also an important mode to regulate mitochondrial dynamics and initiation of mitophagy pathways. Whereas inner mitochondrial compartments are equipped with specific proteases, the ubiquitin-proteasome system is a central player in protein surveillance on the mitochondrial surface. In this review, we summarize our current knowledge about the molecular mechanisms that govern quality control of proteins at the outer mitochondrial membrane.Fabian den BraveArushi GuptaThomas BeckerFrontiers Media S.A.articlemitochondriaprotein sortingprotein quality controlCdc48TOM complexBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria protein sorting protein quality control Cdc48 TOM complex Biology (General) QH301-705.5
spellingShingle	mitochondria protein sorting protein quality control Cdc48 TOM complex Biology (General) QH301-705.5 Fabian den Brave Arushi Gupta Thomas Becker Protein Quality Control at the Mitochondrial Surface
description	Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of metabolites and the formation of a signaling platform in apoptosis and innate immunity. The translocase of the outer membrane (TOM complex) forms the entry gate for the vast majority of precursor proteins that are produced on cytosolic ribosomes. Surveillance of the functionality of outer membrane proteins is critical for mitochondrial functions and biogenesis. Quality control mechanisms remove defective and mistargeted proteins from the outer membrane as well as precursor proteins that clog the TOM complex. Selective degradation of single proteins is also an important mode to regulate mitochondrial dynamics and initiation of mitophagy pathways. Whereas inner mitochondrial compartments are equipped with specific proteases, the ubiquitin-proteasome system is a central player in protein surveillance on the mitochondrial surface. In this review, we summarize our current knowledge about the molecular mechanisms that govern quality control of proteins at the outer mitochondrial membrane.
format	article
author	Fabian den Brave Arushi Gupta Thomas Becker
author_facet	Fabian den Brave Arushi Gupta Thomas Becker
author_sort	Fabian den Brave
title	Protein Quality Control at the Mitochondrial Surface
title_short	Protein Quality Control at the Mitochondrial Surface
title_full	Protein Quality Control at the Mitochondrial Surface
title_fullStr	Protein Quality Control at the Mitochondrial Surface
title_full_unstemmed	Protein Quality Control at the Mitochondrial Surface
title_sort	protein quality control at the mitochondrial surface
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9a8d6a10ecf54c79b54f7c697e4fefbd
work_keys_str_mv	AT fabiandenbrave proteinqualitycontrolatthemitochondrialsurface AT arushigupta proteinqualitycontrolatthemitochondrialsurface AT thomasbecker proteinqualitycontrolatthemitochondrialsurface
_version_	1718373886408523776

Protein Quality Control at the Mitochondrial Surface

Ejemplares similares