Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.

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Autores principales:	Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a90abcae67c4e6d8be26b81b3d9af93
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spelling	oai:doaj.org-article:9a90abcae67c4e6d8be26b81b3d9af932021-12-02T14:40:29ZLoss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas10.1038/s41467-020-16044-82041-1723https://doaj.org/article/9a90abcae67c4e6d8be26b81b3d9af932020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16044-8https://doaj.org/toc/2041-1723Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.Kimiko InoueNarumi OgonukiSatoshi KamimuraHiroki InoueShogo MatobaMichiko HiroseArata HondaKento MiuraMasashi HadaAyumi HasegawaNaomi WatanabeYukiko DodoKeiji MochidaAtsuo OguraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kimiko Inoue Narumi Ogonuki Satoshi Kamimura Hiroki Inoue Shogo Matoba Michiko Hirose Arata Honda Kento Miura Masashi Hada Ayumi Hasegawa Naomi Watanabe Yukiko Dodo Keiji Mochida Atsuo Ogura Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
description	Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.
format	article
author	Kimiko Inoue Narumi Ogonuki Satoshi Kamimura Hiroki Inoue Shogo Matoba Michiko Hirose Arata Honda Kento Miura Masashi Hada Ayumi Hasegawa Naomi Watanabe Yukiko Dodo Keiji Mochida Atsuo Ogura
author_facet	Kimiko Inoue Narumi Ogonuki Satoshi Kamimura Hiroki Inoue Shogo Matoba Michiko Hirose Arata Honda Kento Miura Masashi Hada Ayumi Hasegawa Naomi Watanabe Yukiko Dodo Keiji Mochida Atsuo Ogura
author_sort	Kimiko Inoue
title	Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_short	Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_full	Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_fullStr	Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_full_unstemmed	Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_sort	loss of h3k27me3 imprinting in the sfmbt2 mirna cluster causes enlargement of cloned mouse placentas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9a90abcae67c4e6d8be26b81b3d9af93
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Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

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