Simulated evolution of protein-protein interaction networks with realistic topology.

We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate interactions. (2) Neofunctionalization, in which a mutation leads to a...

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Autores principales: G Jack Peterson, Steve Pressé, Kristin S Peterson, Ken A Dill
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/9a92a006a67d4041b32984a651dc0582
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