Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
Ali MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranObjective: The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressur...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2011
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| Acceso en línea: | https://doaj.org/article/9a949e02b48346b492936aefc5763c05 |
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| Sumario: | Ali MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranObjective: The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressure (IOP).Methods: Forty eyes from 40 patients referred to the Nikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, Iran, were enrolled in a randomized clinical trial. Patients with high-risk open angle glaucoma were allocated to receive either subconjunctival TMMC or T5-FU.Results: Mean overall preoperative IOP was 30.8 mmHg. Mean preoperative IOPs in the TMMC and T5-FU groups were 31.2 ± 9.8 and 30.6 ± 9.9 mmHg, respectively. Postoperatively, mean IOPs were 11.4.3 ± 4.9 and 13.6 ± 3.9 mmHg, respectively for TMMC and T5-FU groups after 6 months. In spite of some existing descriptive differences in IOP between the groups, statistical tests showed no difference in mean and median IOP. Three cases of hypotonia (IOP < 6 mmHg) and 1 case of epithelial keratitis were detected.Conclusion: TMMC and T5-FU appeared to have similar efficacy in lowering IOP.Keywords: glaucoma, trabeculectomy, mitomycin C, 5-fluorouracil |
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