Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial

Ali MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranObjective: The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressur...

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Auteur principal:	Mostafaei A
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2011
Sujets:	Ophthalmology RE1-994
Accès en ligne:	https://doaj.org/article/9a949e02b48346b492936aefc5763c05
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spelling	oai:doaj.org-article:9a949e02b48346b492936aefc5763c052021-12-02T02:04:43ZAugmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial1177-54671177-5483https://doaj.org/article/9a949e02b48346b492936aefc5763c052011-04-01T00:00:00Zhttp://www.dovepress.com/augmenting-trabeculectomy-in-glaucoma-with-subconjunctival-mitomycin-c-a7143https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ali MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranObjective: The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressure (IOP).Methods: Forty eyes from 40 patients referred to the Nikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, Iran, were enrolled in a randomized clinical trial. Patients with high-risk open angle glaucoma were allocated to receive either subconjunctival TMMC or T5-FU.Results: Mean overall preoperative IOP was 30.8 mmHg. Mean preoperative IOPs in the TMMC and T5-FU groups were 31.2 &plusmn; 9.8 and 30.6 &plusmn; 9.9 mmHg, respectively. Postoperatively, mean IOPs were 11.4.3 &plusmn; 4.9 and 13.6 &plusmn; 3.9 mmHg, respectively for TMMC and T5-FU groups after 6 months. In spite of some existing descriptive differences in IOP between the groups, statistical tests showed no difference in mean and median IOP. Three cases of hypotonia (IOP &lt; 6 mmHg) and 1 case of epithelial keratitis were detected.Conclusion: TMMC and T5-FU appeared to have similar efficacy in lowering IOP.Keywords: glaucoma, trabeculectomy, mitomycin C, 5-fluorouracil Mostafaei ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 491-494 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mostafaei A Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
description	Ali MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranObjective: The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressure (IOP).Methods: Forty eyes from 40 patients referred to the Nikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, Iran, were enrolled in a randomized clinical trial. Patients with high-risk open angle glaucoma were allocated to receive either subconjunctival TMMC or T5-FU.Results: Mean overall preoperative IOP was 30.8 mmHg. Mean preoperative IOPs in the TMMC and T5-FU groups were 31.2 &plusmn; 9.8 and 30.6 &plusmn; 9.9 mmHg, respectively. Postoperatively, mean IOPs were 11.4.3 &plusmn; 4.9 and 13.6 &plusmn; 3.9 mmHg, respectively for TMMC and T5-FU groups after 6 months. In spite of some existing descriptive differences in IOP between the groups, statistical tests showed no difference in mean and median IOP. Three cases of hypotonia (IOP &lt; 6 mmHg) and 1 case of epithelial keratitis were detected.Conclusion: TMMC and T5-FU appeared to have similar efficacy in lowering IOP.Keywords: glaucoma, trabeculectomy, mitomycin C, 5-fluorouracil
format	article
author	Mostafaei A
author_facet	Mostafaei A
author_sort	Mostafaei A
title	Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
title_short	Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
title_full	Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
title_fullStr	Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
title_full_unstemmed	Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
title_sort	augmenting trabeculectomy in glaucoma with subconjunctival mitomycin c versus subconjunctival 5-fluorouracil: a randomized clinical trial
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/9a949e02b48346b492936aefc5763c05
work_keys_str_mv	AT mostafaeia augmentingtrabeculectomyinglaucomawithsubconjunctivalmitomycincversussubconjunctival5fluorouracilarandomizedclinicaltrial
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Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial

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