Negri bodies are viral factories with properties of liquid organelles

Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.

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Detalles Bibliográficos
Autores principales: Jovan Nikolic, Romain Le Bars, Zoé Lama, Nathalie Scrima, Cécile Lagaudrière-Gesbert, Yves Gaudin, Danielle Blondel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/9a955e81f9324d589e3ef61679b3fd39
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Sumario:Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.