Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion

Susumu Sakimoto, Motohiro Kamei, Mihoko Suzuki, Shinsaku Yano, Nagakazu Matsumura, Hirokazu Sakaguchi, Fumi Gomi, Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, JapanBackground: To study the relationship between retinal perfusion around the macula and...

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Autores principales:	Sakaguchi H, Matsumura N, Yano S, Suzuki M, Kamei M, Sakimoto S, Gomi F, Nishida K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9a962511aa204cd1838bcbefee97007c
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spelling	oai:doaj.org-article:9a962511aa204cd1838bcbefee97007c2021-12-02T00:08:49ZRelationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion1177-54671177-5483https://doaj.org/article/9a962511aa204cd1838bcbefee97007c2012-12-01T00:00:00Zhttp://www.dovepress.com/relationship-between-grades-of-macular-perfusion-and-foveal-thickness--a11843https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Susumu Sakimoto, Motohiro Kamei, Mihoko Suzuki, Shinsaku Yano, Nagakazu Matsumura, Hirokazu Sakaguchi, Fumi Gomi, Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, JapanBackground: To study the relationship between retinal perfusion around the macula and the foveal thickness in branch retinal vein occlusion (BRVO). Methods: Seventy-four eyes of 74 consecutive patients with BRVO were enrolled. We developed a new grading system to evaluate the status of retinal perfusion around the macula in three grades: full perfusion area (FPA), partial perfusion area (PPA), and nonperfusion area (NPA), using fluorescein angiography. The correlation was assessed between these grades and the central foveal thickness (CFT) measured by optical coherence tomography. We also determined the area with the closest correlation between the perfusion status and the foveal thickness by comparing the correlation coefficient in areas of 1-, 2-, and 3-disc diameter (DD) horizontal hemicircles centered at the fovea. The correlation was determined between the extent of each perfusion grade and CFT. Results: We found a significant negative correlation between the CFT and the FPA (r = 0.31, P = 0.006) and a significant positive correlation between the CFT and the PPA (r = 0.45, P &lt; 0.001) in the three areas. The most significant correlations were found in the 2-DD area. Interestingly, the NPA has not correlated with the foveal thickness in any areas.Conclusion: The areas of partial but not complete capillary loss seem to be responsible for the macular edema associated with BRVO. Treatments targeting leakage from the dilated capillaries in the PPA should be investigated. Keywords: branch retinal vein occlusion, macular perfusion, foveal thickness, macular edemaSakaguchi HMatsumura NYano SSuzuki MKamei MSakimoto SGomi FNishida KDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 39-45 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Sakaguchi H Matsumura N Yano S Suzuki M Kamei M Sakimoto S Gomi F Nishida K Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
description	Susumu Sakimoto, Motohiro Kamei, Mihoko Suzuki, Shinsaku Yano, Nagakazu Matsumura, Hirokazu Sakaguchi, Fumi Gomi, Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, JapanBackground: To study the relationship between retinal perfusion around the macula and the foveal thickness in branch retinal vein occlusion (BRVO). Methods: Seventy-four eyes of 74 consecutive patients with BRVO were enrolled. We developed a new grading system to evaluate the status of retinal perfusion around the macula in three grades: full perfusion area (FPA), partial perfusion area (PPA), and nonperfusion area (NPA), using fluorescein angiography. The correlation was assessed between these grades and the central foveal thickness (CFT) measured by optical coherence tomography. We also determined the area with the closest correlation between the perfusion status and the foveal thickness by comparing the correlation coefficient in areas of 1-, 2-, and 3-disc diameter (DD) horizontal hemicircles centered at the fovea. The correlation was determined between the extent of each perfusion grade and CFT. Results: We found a significant negative correlation between the CFT and the FPA (r = 0.31, P = 0.006) and a significant positive correlation between the CFT and the PPA (r = 0.45, P &lt; 0.001) in the three areas. The most significant correlations were found in the 2-DD area. Interestingly, the NPA has not correlated with the foveal thickness in any areas.Conclusion: The areas of partial but not complete capillary loss seem to be responsible for the macular edema associated with BRVO. Treatments targeting leakage from the dilated capillaries in the PPA should be investigated. Keywords: branch retinal vein occlusion, macular perfusion, foveal thickness, macular edema
format	article
author	Sakaguchi H Matsumura N Yano S Suzuki M Kamei M Sakimoto S Gomi F Nishida K
author_facet	Sakaguchi H Matsumura N Yano S Suzuki M Kamei M Sakimoto S Gomi F Nishida K
author_sort	Sakaguchi H
title	Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
title_short	Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
title_full	Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
title_fullStr	Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
title_full_unstemmed	Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
title_sort	relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9a962511aa204cd1838bcbefee97007c
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Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion

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