Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia

Abstract There are currently no serum-based evaluations that can corroborate the severity of peripheral artery disease (PAD). In this cross-sectional study, we assessed the prevalence of elevated serum fatty acid synthase (cFAS) in patients with chronic limb-threatening ischemia (CLTI) and evaluated...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shirli Tay, Gayan S. De Silva, Connor M. Engel, Nikolai Harroun, Amanda S. Penrose, Kshitij A. Desai, Yan Yan, Clay F. Semenkovich, Mohamed A. Zayed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a974cab434647dba598d68943591583
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a974cab434647dba598d68943591583
record_format	dspace
spelling	oai:doaj.org-article:9a974cab434647dba598d689435915832021-12-02T17:37:28ZPrevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia10.1038/s41598-021-98479-72045-2322https://doaj.org/article/9a974cab434647dba598d689435915832021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98479-7https://doaj.org/toc/2045-2322Abstract There are currently no serum-based evaluations that can corroborate the severity of peripheral artery disease (PAD). In this cross-sectional study, we assessed the prevalence of elevated serum fatty acid synthase (cFAS) in patients with chronic limb-threatening ischemia (CLTI) and evaluated the accuracy of its use in detecting this condition. Preoperative fasting serum samples from 87 patients undergoing vascular intervention were collected between October 2014 and September 2016. Median age was 62 years, with 56 (64%) men, and 32 (37%) with CLTI. We found that elevated cFAS content (OR 1.17; 95% CI 1.04–1.31), type 2 diabetes (T2D; OR 5.22; 95% CI 1.77–15.4), and smoking (OR 3.53; 95% CI 1.19–10.5) were independently associated with CLTI and could detect the presence of CLTI with 83% accuracy (95% CI 0.74–0.92). Furthermore, serum FAS content was positively correlated with FAS content in femoral artery plaque in patients with severe PAD ( $${R}^{2}$$ R 2 = 0.22; P = 0.023). Finally, significantly higher co-localization of FAS and ApoB were observed within lower extremity arterial media (P < .001). Our findings indicate that serum FAS content is a marker for disease severity in patients with PAD, independent of concomitant T2D and smoking, and may play a key role in FAS and ApoB peripheral plaque progression.Shirli TayGayan S. De SilvaConnor M. EngelNikolai HarrounAmanda S. PenroseKshitij A. DesaiYan YanClay F. SemenkovichMohamed A. ZayedNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shirli Tay Gayan S. De Silva Connor M. Engel Nikolai Harroun Amanda S. Penrose Kshitij A. Desai Yan Yan Clay F. Semenkovich Mohamed A. Zayed Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
description	Abstract There are currently no serum-based evaluations that can corroborate the severity of peripheral artery disease (PAD). In this cross-sectional study, we assessed the prevalence of elevated serum fatty acid synthase (cFAS) in patients with chronic limb-threatening ischemia (CLTI) and evaluated the accuracy of its use in detecting this condition. Preoperative fasting serum samples from 87 patients undergoing vascular intervention were collected between October 2014 and September 2016. Median age was 62 years, with 56 (64%) men, and 32 (37%) with CLTI. We found that elevated cFAS content (OR 1.17; 95% CI 1.04–1.31), type 2 diabetes (T2D; OR 5.22; 95% CI 1.77–15.4), and smoking (OR 3.53; 95% CI 1.19–10.5) were independently associated with CLTI and could detect the presence of CLTI with 83% accuracy (95% CI 0.74–0.92). Furthermore, serum FAS content was positively correlated with FAS content in femoral artery plaque in patients with severe PAD ( $${R}^{2}$$ R 2 = 0.22; P = 0.023). Finally, significantly higher co-localization of FAS and ApoB were observed within lower extremity arterial media (P < .001). Our findings indicate that serum FAS content is a marker for disease severity in patients with PAD, independent of concomitant T2D and smoking, and may play a key role in FAS and ApoB peripheral plaque progression.
format	article
author	Shirli Tay Gayan S. De Silva Connor M. Engel Nikolai Harroun Amanda S. Penrose Kshitij A. Desai Yan Yan Clay F. Semenkovich Mohamed A. Zayed
author_facet	Shirli Tay Gayan S. De Silva Connor M. Engel Nikolai Harroun Amanda S. Penrose Kshitij A. Desai Yan Yan Clay F. Semenkovich Mohamed A. Zayed
author_sort	Shirli Tay
title	Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
title_short	Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
title_full	Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
title_fullStr	Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
title_full_unstemmed	Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
title_sort	prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9a974cab434647dba598d68943591583
work_keys_str_mv	AT shirlitay prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT gayansdesilva prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT connormengel prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT nikolaiharroun prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT amandaspenrose prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT kshitijadesai prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT yanyan prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT clayfsemenkovich prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia AT mohamedazayed prevalenceofelevatedserumfattyacidsynthaseinchroniclimbthreateningischemia
_version_	1718379898143244288

Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia

Ejemplares similares